This paper presents the local interaction simulation approach (LISA) for efficient modeling of linear and nonlinear ultrasonic guided wave active sensing of complex structures. Three major modeling challenges are considered: material anisotropy with damping effects, nonlinear interactions between guided waves and structural damage, as well as geometric complexity of waveguides. To demonstrate LISA's prowess in addressing such challenges, carefully designed numerical case studies are presented. First, guided wave propagation and attenuation in carbon fiber composite panels are simulated. The numerical results are compared with experimental measurements obtained from scanning laser Doppler vibrometry (SLDV) to illustrate LISA's capability in modeling damped wave propagation in anisotropic medium. Second, nonlinear interactions between guided waves and structural damage are modeled by integrating contact dynamics into the LISA formulations. Comparison with commercial finite element software reveals that LISA can accurately simulate nonlinear ultrasonics but with much higher efficiency. Finally, guided wave propagation in geometrically complex waveguides is studied. The numerical example of multimodal guided wave propagation in a rail track structure with a fatigue crack is presented, demonstrating LISA's versatility to model complex waveguides and arbitrary damage profiles. This paper serves as a comprehensive, systematic showcase of LISA's superb capability for efficient modeling of transient dynamic guided wave phenomena in structural health monitoring (SHM).