Acoustofluidics 5: Building microfluidic acoustic resonators

Lenshof, Andreas; Evander, Mikael; Laurell, Thomas; Nilsson, Johan

doi:10.1039/c1lc20996e

Cited by 218 publications

(185 citation statements)

References 57 publications

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“…The standing SAW leaks into the adjacent fluid medium and establishes a differential pressure field in the fluid; this field generates acoustic radiation forces that act on suspended particles. The acoustic radiation forces drive particles to nodes or antinodes in the acoustic pressure field, depending on their elastic properties (15,(38)(39)(40)(41)(42)(43). Most objects, including polystyrene beads, cells, and C. elegans, are pushed to the pressure nodes because of density and/or compressibility variations relative to the background medium.…”

Section: Resultsmentioning

confidence: 99%

“…To date, many acoustic-based particle manipulation functions (e.g., focusing, separating, sorting, mixing, and patterning) have been realized (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43). None of these approaches, however, have achieved the dexterity of optical tweezers; in other words, none of the previous acoustic-based methods are capable of precisely manipulating single microparticles or cells along an arbitrary path in two dimensions.…”

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confidence: 99%

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On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves

Ding

Lin

Kiraly

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

801

590

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Techniques that can dexterously manipulate single particles, cells, and organisms are invaluable for many applications in biology, chemistry, engineering, and physics. Here, we demonstrate standing surface acoustic wave based “acoustic tweezers” that can trap and manipulate single microparticles, cells, and entire organisms (i.e., Caenorhabditis elegans ) in a single-layer microfluidic chip. Our acoustic tweezers utilize the wide resonance band of chirped interdigital transducers to achieve real-time control of a standing surface acoustic wave field, which enables flexible manipulation of most known microparticles. The power density required by our acoustic device is significantly lower than its optical counterparts (10,000,000 times less than optical tweezers and 100 times less than optoelectronic tweezers), which renders the technique more biocompatible and amenable to miniaturization. Cell-viability tests were conducted to verify the tweezers’ compatibility with biological objects. With its advantages in biocompatibility, miniaturization, and versatility, the acoustic tweezers presented here will become a powerful tool for many disciplines of science and engineering.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves

Ding

Lin

Kiraly

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

801

590

View full text Add to dashboard Cite

show abstract

“…For bacteria suspended in a fluid medium  is typically positive, 43 In addition to the axial component of the primary acoustic radiation force, a lateral primary acoustic radiation force arises from lateral velocity gradients, 58,59 which translates particles within a plane parallel to the transducer.…”

Section: Forces On Bacteria In Acoustofluidic Devicesmentioning

confidence: 99%

A thin-reflector microfluidic resonator for continuous-flow concentration of microorganisms: a new approach to water quality analysis using acoustofluidics

et al. 2014

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An acoustofluidic device has been developed for concentrating vegetative bacteria in a continuous-flow format. We show that it is possible to overcome the disruptive effects of acoustic streaming which typically dominate for small target particles, and demonstrate flow rates compatible with the testing of drinking water. The device consists of a thin-reflector multi-layered resonator, in which bacteria in suspension are levitated towards a glass surface under the action of acoustic radiation forces. In order to achieve robust device performance over long-term operation, functional tests have been carried out to (i) maintain device integrity over time and stabilise its resonance frequency, (ii) optimise the operational acoustic parameters, and (iii) minimise bacterial adhesion on the inner surfaces. Using the developed device, a significant increase in bacterial concentration has been achieved, up to a maximum of ~60-fold. The concentration performance of thin-reflector resonators was found to be superior to comparable half-wave resonators.

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“…1(a) shows the schematic presentation of a classical layered acoustofluidic particle manipulation device, which is, typically, composed of four layers: the transducer, the carrier layer, the fluid channel, and the reflector layer. 38,39 In this paper, only the fluid layer was considered for the numerical efficiency of 3D acoustic and streaming simulations, which is appropriate as it has been shown previously 35 that this simplified model is sufficient to demonstrate the fundamental behaviour of streaming fields. For a given application, however, a full model may be required to capture more complex combinations of boundary movement to determine which resonance is excited in the fluid layer.…”

Section: Modellingmentioning

confidence: 99%

“…While there are various resonant acoustofluidic systems, we investigated here the half-wave resonance in the z-direction, which is a widely used system for particle and cell manipulation. [38][39][40][41][42][43][44][45][46][47] The origin of the coordinates in these models was set at the centre of the fluid channels such that the fluid channels are located within coordinates:…”

Section: Modellingmentioning

confidence: 99%

Modal Rayleigh-like streaming in layered acoustofluidic devices

2016

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Classical Rayleigh streaming is well known and can be modelled using Nyborg’s limiting velocity method as driven by fluid velocities adjacent to the walls parallel to the axis of the main acoustic resonance. We have demonstrated previously the existence and the mechanism of four-quadrant transducer plane streaming patterns in thin-layered acoustofluidic devices which are driven by the limiting velocities on the walls perpendicular to the axis of the main acoustic propagation. We have recently found experimentally that there is a third case which resembles Rayleigh streaming but is a more complex pattern related to three-dimensional cavity modes of an enclosure. This streaming has vortex sizes related to the effective wavelength in each cavity axis of the modes which can be much larger than those found in the one-dimensional case with Rayleigh streaming. We will call this here modal Rayleigh-like streaming and show that it can be important in layered acoustofluidic manipulation devices. This paper seeks to establish the conditions under which each of these is dominant and shows how the limiting velocity field for each relates to different parts of the complex acoustic intensity patterns at the driving boundaries.

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Acoustofluidics 5: Building microfluidic acoustic resonators

Cited by 218 publications

References 57 publications

On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves

On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves

A thin-reflector microfluidic resonator for continuous-flow concentration of microorganisms: a new approach to water quality analysis using acoustofluidics

Modal Rayleigh-like streaming in layered acoustofluidic devices

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