Acquired Agammaglobulinemia with Multiple Allergies and Pernicious Anemia

Hypogammaglobulinaemia and Pernicious Anaemia

“…Even if it is known that patients with hypogammaglobulinae mia can develop allergy (10,15,39,49), hypersensitivity to gamma globulin appears to be rare. Thus, Stampfli et al (57) did not observe any untoward reactions and G ross et al (22) reported that more severe reactions are rare but that reactions, even anaphy lactic shock, have occasionally been observed.…”

“…The combination of hypogammaglobulinaemia and pernicious anaemia has been described in 4 cases (10,28,32,34), but it has apparently received little attention. It is not even mentioned by R o y er in a recent review of haematologic aspects of hypogammaglobulinaemia (51).…”

Multiple Neuropathic Joints? Syphilitic

“…The association of adult hyEpogammaglobuliniemia and:pernicious anemia has been described previously (Klayman & Brandborg, 1955, Lewis & Brown-1957, Crowder et al 1959. Addendum: A further vitamin B12 absorption test has been carried out since this patient was demonstrated (Dr D G Penington).…”

“…The critical level of serum y-globulin for 'normal' resistance to pyogenic infection is thought to be 0-15-0-20 g/100 ml. The normal range of values for serum y-globulin in adults is 0-8-12 g/100 ml (Gell 1957). Young plasma cells or their precursors are considered to play an important role in antibody production (Sundberg 1955).…”

Pernicious Anaemia, Myxoedema, and Hypogammaglobulinaemia--A Family Study

“…Gibbs andPryor (1961) andPaull (1961) have added further cases of pernicious anaemia with hypogammaglobulinaemia. Crowder, Thompson, and Kupfer (1959) reported the case of a further patient with this combination who was also subject to multiple allergies. Case 2 in the present series therefore provides a second example of this syndrome.…”