Acquired Bilateral Central Vision Loss in a Young Adult Due to “Poppers Maculopathy”

Law, Geoffrey; Ching, Geoffrey; Docherty, Gavin; Navajas, Eduardo V.

doi:10.31546/jjoar.1004

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Law et al report a case of a 35-year-old healthy man who presented with bilateral blurry vision 12 h after a one-time use of alkyl nitrites. Fundus exam showed a yellow spot at the fovea, and OCT showed disruption of the foveal photoreceptors [73]. Similar findings were reported in another report of a 36-year-old man with poppers maculopathy who underwent multimodal imaging; of note, no vascular changes were noted on OCTA [74].…”

Section: Alkyl Nitritessupporting

confidence: 87%

Update on Retinal Drug Toxicities

Hsu

Ponugoti

Deaner

et al. 2021

Curr Ophthalmol Rep

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Purpose of Review This review aims to provide an update on the clinical presentations and diagnostic findings of drug-induced retinal toxicities. Recent Findings Several newly FDA-approved medications have been associated with acute retinal toxicities, including brolucizumab, MEK inhibitors, ulixertinib, and FGFR inhibitors. Additionally, as previously believed-to-be well-tolerated medications, such as pentosan sulfate sodium, anti-retroviral therapies, and certain intraoperative ocular medications, are used more frequently or for longer periods of time, associated toxic retinopathies and inflammatory reactions have been reported. Finally, advances in ocular imaging have revealed novel findings in hydroxychloroquine and tamoxifen maculopathies. Summary Discovery of new medications, increased frequency of use, and longer-term use have led to increased reports of retinal toxicities. Advances in retinal imaging have allowed for earlier detection of subclinical changes associated with these medications, which may help prevent progression of disease. However, more research is needed to determine the point at which vision loss becomes irreversible. Risks and benefits must be assessed prior to discontinuation of the offending, but potentially lifesaving, therapy.

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Section: Alkyl Nitritessupporting

confidence: 87%

Update on Retinal Drug Toxicities

Hsu

Ponugoti

Deaner

et al. 2021

Curr Ophthalmol Rep

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“…Only three articles (7 patients, 14 eyes) came from non-European countries. Eight from Australia(2), four from Canada (15,16), and one from USA (17).…”

Section: Resultsmentioning

confidence: 99%

Poppers maculopathy: A quantitative review of previous literature

Martín-Moro

Almagro

Ventura-Abreu

et al. 2021

Seminars in Ophthalmology

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Aim: To review the available literature on poppers maculopathy (PM).Material and methods: 64 patients (60 with bilateral and 4 with unilateral involvement), for a total of 124 eyes reported in Pubmed, Google Scholar and Embase. Patterns were analyzed according to country, age, gender, sexual orientation, HIV status, consumption habits, visual acuity at presentation (VAP), final visual acuity (VAF) and optical coherence tomography (OCT).Results: Most cases (110 eyes) of PM were reported in European countries and affected middle-aged men (only 8 eyes from female users). The median age was 38.7 years (SD=10.5 years). Final visual acuity (Median=0.8; Interquartile range: 0.67-1) was higher than visual acuity at presentation (Median=0.67; Interquartile range: 0.4-0.8). Many articles lack data on sexual orientation and HIV status as this is considered very personal information. VAF was higher than VAP. One third of the eyes (40 eyes) developed PM after a single exposure. No significant differences were found between eyes that developed PM after a single exposure and those which developed the condition after several exposures. The most commonly reported pattern was an interruption of the ellipsoid line (68 eyes).Conclusion: PM is more prevalent in Europe or European ophthalmologists are more likely to diagnose PM. PM usually affects middle-aged men given that this condition generally appears with chronic exposure to poppers. VAF was higher than VAP, suggesting that this toxicity is in part reversible. Information about HIV status was not provided in most recent articles, thus it is not possible to make inferences about the possible implication of HIV drugs as cofactors for the development of this retinal toxicity.

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Acquired Bilateral Central Vision Loss in a Young Adult Due to “Poppers Maculopathy”

Cited by 2 publications

References 8 publications

Update on Retinal Drug Toxicities

Update on Retinal Drug Toxicities

Poppers maculopathy: A quantitative review of previous literature

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