Acquired cholesteatoma: summary of the cascade of molecular events

Louw, Louise

doi:10.1017/s0022215113000601

Cited by 31 publications

(24 citation statements)

References 65 publications

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“…LPS stimulates osteoclastogenesis directly from mononuclear osteoclast precursors. Furthermore, it stimulates production of interleukin (IL)-1β, IL-6, prostaglandin (PG) E2, and tumor necrosis factor alpha (TNF-α) from macrophages and monocytes with resultant increase in inflammatory activity [8,61-65]. Jung et al [66] performed an experimental study to investigate the role of PA in the aggressiveness of induced cholesteatoma in gerbils and found that infected cholesteatomas showed more expansion and became more aggressive than uninfected control subjects.…”

Section: Mechanisms Of Bone Resorption In Cholesteatomamentioning

confidence: 99%

“…The progressive bone erosion made by cholesteatoma can lead to permanent hearing loss, vestibular dysfunction, facial palsy, and more fatal intracranial complications [7]. It was found that a complex process with integration of both molecular and cellular events could play the major role in cholesteatoma formation, growth as well as its destructive pattern [1,8,9]. …”

Section: Introductionmentioning

confidence: 99%

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Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed

Nakata

Sayed

et al. 2016

Clin Exp Otorhinolaryngol

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Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications.

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Section: Mechanisms Of Bone Resorption In Cholesteatomamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed

Nakata

Sayed

et al. 2016

Clin Exp Otorhinolaryngol

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“…In the perimatrix of acquired cholesteatoma, there is inflammatory cell infiltration such as lymphocyte and polymorphonuclear cells. [12][13][14] Acute inflammation is triggered by events such as bacterial or viral infections, trauma, tissue necrosis, and immune reactions. T lymphocytes play a greater role in the response of the body to viral infections.…”

Section: Discussionmentioning

confidence: 99%

Is There A Systemıc Inflammatory Effect of Cholesteatoma?

Kılıçkaya

Aynali

Tüz

et al. 2016

Int Arch Otorhinolaryngol

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Introduction Inflammation causes squamous epithelial transformation of the mucosa in the middle ear cavity and plays a role in the onset, growth, spread, and recurrence of cholesteatoma. Objectives The objective of this study is to investigate the systemic inflammatory effect in chronic otitis with cholesteatoma. Methods The study included a total of 311 patients comprising 156 patients with a pathology diagnosis of cholesteatoma and a control group of 155 with no active inflammation. The Neutrophil-to-lymphocyte Ratio (NLR) was calculated by dividing the neutrophil value by the lymphocyte value. Results The mean NLR was 1.94 ± 0.91 in the patients with cholesteatoma and 1.94 ± 0.85 in the control group. We determined no statistically significant difference between the groups in respect of NLR (p = 0.983). We calculated the NLR as 2.01 ± 1.00 in patients with ossicle erosion and 1.82 ± 0.69 in those without ossicle erosion, 1.86 ± 0.85 in patients with bone erosion and 1.98 ± 0.95 in those without bone erosion. We determined no statistical difference between these values (p = 0.175). Conclusion The results of this study showed that NLR had no predictive value in respect of bone erosions and associated complications in patients with cholesteatoma. The inflammatory effect of cholesteatoma is not systemic but remains more local.

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“…16 Recently, Louw reviewed the role of microorganism-induced alterations in lipid metabolism in matrix cell apoptosis and cholesteatoma deterioration. 17 It is therefore likely that fungal elements associated with cholesteatoma play a significant role in the disease progression. The major goal of cholesteatoma surgery is to completely remove keratin and matrix debris from the middle-ear cleft to achieve a safe, stable ear.…”

Section: Discussionmentioning

confidence: 99%

Mycological study on cholesteatoma keratin obtained during primary mastoid surgery

Effat

Madany

2014

J. Laryngol. Otol.

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Acquired cholesteatoma: summary of the cascade of molecular events

Abstract: The role of lipids in this disease is relatively unexplored, but there is evidence in support of fatty acid role-players that needs confirmation. Future directions in lipid research to delineate molecular mechanisms are proposed.

Cited by 31 publications

References 65 publications

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Is There A Systemıc Inflammatory Effect of Cholesteatoma?

Mycological study on cholesteatoma keratin obtained during primary mastoid surgery

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