Acquired Coagulation Disorders Caused by Inhibitors

Acquired factor V inhibitor presenting as life threatening bleeding after initiation of apixaban

“…This condition tends to occur in elderly patients, usually over the age of 65, and it is associated with an increased risk for bleeding and high mortality rate. 6 Secondly, patients with a history of factor V deficiency tend to develop alloantibodies after being exposed to blood/plasma products. Lastly, the most studied and understood risk factor for the development of Factor V autoantibodies is the prior exposure to bovine thrombin preparations, which were previously used as topical haemostatic agents for surgical procedures.…”