Acquired Cytomegalovirus Infection

Hanshaw, James B.; Betts, Robert F.; Simon, Gilbert; Boynton, Ragna C.

doi:10.1056/nejm196503252721202

Cited by 142 publications

(14 citation statements)

References 10 publications

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“…Owing to our own observations, and to reports appearing during the course of this study (Hanshaw et al, 1965;Klemola and KAiridinen, 1965), there was a tendency to select cases particularly with clinically atypical hepatitis and Paul-Bunnell-negative mononucleosis. In some of these patients, and in some others with long-lasting febrile illnesses, there was a significant rise in titre of cytomegalovirus antibodies.…”

Section: Resultsmentioning

confidence: 59%

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Acquired cytomegalovirus infection.

Carlström¹,

Alden²,

Belfrage³

et al. 1968

BMJ

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Section: Resultsmentioning

confidence: 59%

“…Rowe et al (1958) presented evidence indicating a common occurrence in children of postnatal cytomegalovirus infections with a subclinical course. Hanshaw et al (1965) reported a chronic type of hepatitis clinically significant in postnatally acquired cytomegalovirus infection.…”

Section: Discussionmentioning

confidence: 99%

Acquired cytomegalovirus infection.

Carlström¹,

Alden²,

Belfrage³

et al. 1968

BMJ

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“…The relationship of CMV infection and ARTD or hepatitis have been reported (Hanshaw et al 1965 Tazawa and Numazaki 1988). We previously demonstrated the participation of CMV infection in ARID of full-term infants, particularly in patients with hepatitis by a method using a single determination of specific antibodies to CMV antigens, IgG EA and 1gM MA, which are known as specific markers of acute CMV infection or active CMV replication.…”

Section: Discussionmentioning

confidence: 98%

“…The former is well known as a cytomegalic inclusion disease, but the clinical features of the latter is still unclear. During infancy some patients with acute respiratory tract disease (ARTD) or hepatitis also suffer a postnatal CMV infection (Hanshaw et al 1965 ;Olson et al 1970;Peller and Goetz 1978;Numazaki et al 1980;Stagno et al 1980), but the implications of CMV infection in these diseases still remain unsolved.…”

mentioning

confidence: 99%

Cytomegalovirus infection in low-birth-weight infants with acute respiratory tract disease.

Tazawa

Yamada

Ito

et al. 1989

Tohoku J. Exp. Med.

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To determine a participation of cytomegalovirus (CMV) infection in acute respiratory tract disease (ARTD) of low-birth-weight (LBW) infants, specific antibodies against CMV antigens, IgG antibodies against early antigens of CMV (IgG EA) and IgM antibodies against membrane antigens of CMV (IgG MA) were analyzed. The frequency of IgG EA in patients with ARTD was higher than that in controls (46% vs. 32%), and the geometrical mean titer (GMT) of IgG EA in the patients was also higher than that in controls (50.2 vs. 20.1). Five of 15 ARTD patients had IgM MA, and the frequency was significantly higher than that of controls (33% vs. 1.3%, p <0.01). Eleven of 15 LBW patients with ARTD had a history of blood transfusions during the neonatal period, and 5 of them had significant IgM MA indicating active CMV infection. All 4 LBW patients without blood transfusion were negative for IgM MA. These results suggest a close relationship of CMV infection to ARTD of LBW infants, but it remains for further studies whether blood transfusion is a primary source of CMV infection in LBW infants.cytomegalovirus ; low-birth-weight infants ; acute respiratory tract disease

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“…WJaLLnR et al (28) are of the opinion that the human cytomegaloviruses do not constitute a single serotype, and therefore, they, together with a few other investigators often use homologous strains (17,22,25) or a few laboratory strains (9,10,12,13,16,18,20,27,28) in the test systems. Others (6--8, 14, 23) including ourselves (1--5) have, however, had very good results using just one laboratory strain.…”

Section: Hk Anders]~nmentioning

confidence: 99%

Cytomegalovirus neutralization by plaque reduction

1971

Archiv f Virusforschung

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SummaryThe neutralization of cytomega]ovirus strain Ad 169 has been studied in a plaque reduction system. The neutralization of cytomegalovirus seems to follow the principles for neutralization of other animal viruses. The kinetics of neutralization are first order, neutralization is linearly dependent of antibody concentration and the rate of neutralization is affected by both temperature and time. The highest degree of neutralization was found, when serum-virusmixtures were incubated at 37 ~ C.The plaque reduction neutralization test was well suited for determination of neutralizing antibodies as the sensibility and reproducibility of the test was found to be rather high. Under the conditions of the experiments the sensitivity of the plaque reduction neutralization test was at least 4-fold higher than that of the tube neutralization test.

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Acquired Cytomegalovirus Infection

Cited by 142 publications

References 10 publications

Acquired cytomegalovirus infection.

Acquired cytomegalovirus infection.

Cytomegalovirus infection in low-birth-weight infants with acute respiratory tract disease.

Cytomegalovirus neutralization by plaque reduction

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