Acquired Darier disease in a patient with metastatic prostate cancer: a paraneoplastic process?

Pararajasingam, Abirami; Ponnambath, Nabil

doi:10.5070/d32611047893

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Late generalized forms are associated with a paraneoplastic syndrome; a literature search reveals three reported cases of acquired DD associated with malignancy; indeed some tumors can secrete factors such as transforming growth factor β which can interfere with the calcium homeostasis of keratinocytes involving or not the SERCA2 pump. 3 Generalized forms can be observed during HIV infection or occur after radiotherapy. 4 Late segmental zosteriform, linear, Blaschko linear or comedonal forms have been described in a few cases.…”

Section: Discussionmentioning

confidence: 99%

Vesiculo-bullous Darier disease late onset in association with polycythemia vera

et al. 2023

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Vesiculo-bullous lesions as well as the late onset are extremely rare features of Darier disease (DD) making positive diagnosis more difficult. Its association with polycythemia vera prompts to look for signs suggestive of malignant hematological transformation. We report a case of a 62-year-old patient, followed in internal medicine since the age of 58 for polycythemia vera. She presented for pruriginous vesiculo-bullous dermatosis evolving for 4 years. On clinical examination, papulo-vesicular plaques were found involving all the folds: inguinal, axillary, inter-gluteal, neck and body with palmo-plantar blisters and pustules. Examination of the toe nails showed alternating red and white longitudinal bands. Abdominal examination showed moderate splenomegaly. Skin biopsy revealed focal acantholysis with supra-basal clefts, dyskeratosis with the presence of round bodies and grains compatible with Darier's disease. A paraneoplastic assessment was made including a thoraco-abdomino-pelvic CT scan, a breast ultrasound and mammography with cervico-vaginal smear, a CT scan of the cavum and a pancreatic MRI, which did not show any progressive malignant process. The patient was put on oral retinoids at a rate of 0.5 mg/kg per day and topical calcipotriol associated with bloodletting to reduce the hematocrit level. The evolution was marked by clinical improvement. The patient was followed in the hematology department and showed no acute leukemia or myelofibrosis or other neoplasms after a 2-year follow-up. We report a case of late DD in a woman followed for polycythemia vera, characterized by a rare vesiculo-bullous presentation and whose causal link remains to be determined.

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Section: Discussionmentioning

confidence: 99%

Vesiculo-bullous Darier disease late onset in association with polycythemia vera

et al. 2023

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Tumor Microenvironment and Dermatological Conditions in Prostate Cancer

Ene,

Capusa,

Nicolae

et al. 2024

Applied Sciences

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Tumor initiation, progression, and invasion are closely related to the tumor microenvironment. Inflammation can modulate the activity of the cells in the TME and contribute to all stages of tumor development. The etiopathogenesis of cutaneous manifestations associated with prostate cancer is unclear. The cutaneous phenotype associated with prostate cancer could be supported by intratumoral heterogeneity, the remodeling of interactions in the tumor microenvironment, and the dynamics of the epithelial–mesenchymal transition. Among the urinary system cancers, prostate cancer presents few cutaneous signs and symptoms, most being diagnosed in the advanced stages of the disease. In this review, we analyze the cutaneous events associated with prostate cancer, represented by direct or indirect manifestations of the primary malignancy and the skin toxicities caused by oncological medications.

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Acquired Darier disease in a patient with metastatic prostate cancer: a paraneoplastic process?

Cited by 2 publications

References 5 publications

Vesiculo-bullous Darier disease late onset in association with polycythemia vera

Vesiculo-bullous Darier disease late onset in association with polycythemia vera

Tumor Microenvironment and Dermatological Conditions in Prostate Cancer

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