Acquired equivalence and distinctiveness of cues: II. Neural manipulations and their implications.

Coutureau, Étienne; Killcross, Simon; Good, Mark Andrew; Marshall, Vanessa; Ward-Robinson, Jasper; Honey, Robert Colin

doi:10.1037/0097-7403.28.4.388

Cited by 62 publications

(85 citation statements)

References 45 publications

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“…It is, however, unlikely that the EC serves as a simple relay for the transmission of information from the sensory thalamus and parahippocampal cortices to the hippocampus (Kerr et al, 2007). Indeed, an increasing number of studies indicate distinct roles of the EC and of the hippocampus proper in information processing (Coutureau et al, 1999(Coutureau et al, , 2002Shohamy et al, 2000;Talnov et al, 2003;Sargolini et al, 2006). Moreover, no persistent activity bridging the long time gap between the CS and US has so far been recorded in the hippocampus proper during trace fear conditioning (Gilmartin and McEchron, 2005).…”

Section: Discussionmentioning

confidence: 99%

A Cholinergic-Dependent Role for the Entorhinal Cortex in Trace Fear Conditioning

Esclassan

Coutureau²,

Scala³

et al. 2009

Journal of Neuroscience

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Trace conditioning is considered a model of higher cognitive involvement in simple associative tasks. Studies of trace conditioning have shown that cortical areas and the hippocampal formation are required to associate events that occur at different times. However, the mechanisms that bridge the trace interval during the acquisition of trace conditioning remain unknown. In four experiments with fear conditioning in rats, we explored the involvement of the entorhinal cortex (EC) in the acquisition of fear under a trace-30 s protocol. We first determined that pretraining neurotoxic lesions of the EC selectively impaired trace-, but not delay-conditioned fear as evaluated by freezing behavior. A local cholinergic deafferentation of the EC using 192-IgG-saporin did not replicate this deficit, presumably because cholinergic interneurons were spared by the toxin. However, pretraining local blockade of EC muscarinic receptors with the M1 antagonist pirenzepine yielded a specific and dose-dependent deficit in trace-conditioned responses. The same microinjections performed after conditioning were without effect on trace fear responses. These effects of blocking M1 receptors are consistent with the notion that conditioned stimulus (CS)-elicited, acetylcholine-dependent persistent activities in the EC are needed to maintain a representation of a tone CS across the trace interval during the acquisition of trace conditioning. This function of the EC is consistent with recent views of this region as a short-term stimulus buffer.

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Section: Discussionmentioning

confidence: 99%

A Cholinergic-Dependent Role for the Entorhinal Cortex in Trace Fear Conditioning

Esclassan

Coutureau²,

Scala³

et al. 2009

Journal of Neuroscience

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“…The application of this theory in explaining the role of the hippocampus in forming configural memory of non-spatial cues has been challenged on several grounds (e.g. [53]). Furthermore, until recently, there were relatively few tests that sought to determine whether the formation of a configural memory for the spatial and temporal properties of cues is reliant upon the hippocampus.…”

Section: Configural Memory For What Where and Whenmentioning

confidence: 99%

Hippocampal synaptic activity, pattern separation and episodic-like memory: implications for mouse models of Alzheimer's disease pathology

Palmer

Good

2011

Biochemical Society Transactions

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The present review summarizes converging evidence from animal and human studies that an early target of amyloid pathology is synaptic activity in the DG (dentate gyrus)/CA3 network. We briefly review the computational significance of the DG/CA3 network in the encoding of episodic memory and present new evidence that the CA3/DG pattern of activation is compromised in a mouse model of amyloid pathology. In addition, we present a new behavioural method to test the prediction that amyloid-related synaptic pathology will disrupt the formation of an integrated episodic-like (what, where and when) memory in mice.

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“…In addition, the results of Group DR versus Group DE in Experiment 2 suggested that shared associations with a US may provide the basis for increases in generalization among otherwise distinctive CSs. Conversely, in studies of "acquired distinctiveness," generalization between similar CSs has been attenuated by pairing them with different outcomes (Coutureau et al, 2002;Delamater, 1998;Honey & Hall, 1989Honey & Ward-Robinson, 2002). For example, Delamater (1998) conducted training in which two auditory stimuli (A1, A2) and two visual stimuli (V1, V2) were each paired with one of two types of food outcome (labeled here as ϩ or #).…”

Section: Methodsmentioning

confidence: 99%

Stimulus specificity of concurrent recovery in the rabbit nictitating membrane response

Weidemann

Kehoe

2005

Learning & Behavior

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Three experiments demonstrated that, following the extinction of an established conditioned stimulus (CS; e.g., tone), the pairing of an orthogonal stimulus from another modality (e.g., light) with the unconditioned stimulus (US) results in strong recovery of responding to the extinguished CS. This recovery occurred to about an equal degree regardless of whether or not initial training contained unambiguous stimulus-reinforcer relationships-that is, consistent CS-US pairings-or some degree of ambiguity, including intramodal discrimination training, partial reinforcement, or even cross-modal discrimination training (tone vs. light). Experiments 1 and 2 demonstrated that this recovery of responding was largely specific to the extinguished CS, but moderate generalization to other stimuli from the same modality did appear. The results are discussed with reference to alternative mechanisms applicable to learning-dependent generalization between otherwise distinct CSs. These models assume that such generalization is mediated by either a shared response, shared reinforcer, shared context, or shared hidden units within a layered neural network. A specific layered network is proposed to explain the present results as well as other types of savings seen previously in conditioning of the rabbit nictitating membrane response.

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Acquired equivalence and distinctiveness of cues: II. Neural manipulations and their implications.

Cited by 62 publications

References 45 publications

A Cholinergic-Dependent Role for the Entorhinal Cortex in Trace Fear Conditioning

A Cholinergic-Dependent Role for the Entorhinal Cortex in Trace Fear Conditioning

Hippocampal synaptic activity, pattern separation and episodic-like memory: implications for mouse models of Alzheimer's disease pathology

Stimulus specificity of concurrent recovery in the rabbit nictitating membrane response

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