Acquired factor X deficiency in a multiple myeloma without amyloidosis: a case report

Coussee, Amber; Alliet, Gudrun; Hervent, Anne-Sophie; Vynckier, Liesbeth; Emmerechts, Jan; Van Hecke, Sam; Persijn, Lies

doi:10.1080/17843286.2023.2265650

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2024

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Cited by 2 publications

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“…Acquired coagulation factor deficiency is another reason for bleeding in MM [ 24 , 25 ]. Several mechanisms were reported to be responsible for acquired coagulation deficiency in MM patients, including the formation of a complex between paraprotein and FX, which is subsequently sequestered by the reticuloendothelial system, IgG4-mediated specific FX inhibitor blocks the activation of FX, and absorption of FX by amyloid fibres in patients concomitant with amyloidosis [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Rediscovering hemostasis abnormalities in multiple myeloma: The new era

Huang,

Wang,

Wang

et al. 2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Rediscovering hemostasis abnormalities in multiple myeloma: The new era

Huang,

Wang,

Wang

et al. 2024

Heliyon

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Navigating the Challenges of Factor X Deficiency: A Case Study

Chaudhary,

Bhavsar,

Mahashabde

2024

Cureus

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The clotting pathway involves intrinsic and extrinsic pathways converging into a common pathway. These pathways require activated factors that sequentially convert prothrombin to thrombin, which then converts fibrinogen to fibrin, forming a stable clot. Clotting factor deficiency impairs this cascade leading to excessive bleeding or bruising due to insufficient clot formation. Here, we present the case of a 47-year-old female who initially complained of epigastric pain. By the third day of admission, she experienced four to five episodes of bleeding gums, resulting in a blood loss of approximately 300 mL. The patient exhibited abnormal prothrombin time (PT) and international normalized ratio (INR) values, leading to a diagnosis of Factor X (FX) deficiency upon further evaluation. This case report emphasizes the need to diagnose coagulopathies such as FX deficiency and how early diagnosis will help not only in patient care and management but also in screening family members who may be affected.

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Acquired factor X deficiency in a multiple myeloma without amyloidosis: a case report

Cited by 2 publications

References 13 publications

Rediscovering hemostasis abnormalities in multiple myeloma: The new era

Rediscovering hemostasis abnormalities in multiple myeloma: The new era

Navigating the Challenges of Factor X Deficiency: A Case Study

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