Acquired heat acclimation in rats subjected to physical exercise under environmental heat stress alleviates brain injury caused by exertional heat stroke

Li, Xin; Xv, Fan; Ma, Lizhen; Xing, Ling; Zhao, Jin-Bao; Zhi, Wei; Wang, Lifeng; Wang, Yan; Mao, Han-Ding; Liu, Shuyuan; Liu, Ya-hua; Song, Qing

doi:10.1016/j.brainres.2023.148393

Cited by 4 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The HA protocol was conducted according to previously reported protocols used by our group, as well as recent advances in HA study ( Cao et al, 2022 ; Huang et al, 2023 ; Li et al, 2023 ). Briefly, rats in the HA group were placed in an artificial climate chamber (LTH-575 N-01; Shanghai Drawell Scientific Instrument Co., Ltd., Shanghai, China) where environmental parameters were maintained at 36 ± 1°C and 55 ± 5% RH for 2 h per day, for 21 days.…”

Section: Methodsmentioning

confidence: 99%

Heat acclimation with probiotics-based ORS supplementation alleviates heat stroke-induced multiple organ dysfunction via improving intestinal thermotolerance and modulating gut microbiota in rats

Li,

Chen,

Wang

et al. 2024

Front. Microbiol.

Self Cite

View full text Add to dashboard Cite

Heat stroke (HS) is a critical condition with extremely high mortality. Heat acclimation (HA) is widely recognized as the best measure to prevent and protect against HS. Preventive administration of oral rehydration salts III (ORSIII) and probiotics have been reported to sustain intestinal function in cases of HS. This study established a rat model of HA that was treated with probiotics-based ORS (ORSP) during consecutive 21-day HA training. The results showed that HA with ORSP could attenuate HS-induced hyperthermia by regulating thermoregulatory response. We also found that HA with ORSP could significantly alleviate HS-induced multiple organ injuries. The expression levels of a series of heat-shock proteins (HSPs), including HSP90, HSP70, HSP60, and HSP40, were significantly up-regulated from the HA training. The increases in intestinal fatty acid binding protein (I-FABP) and D-Lactate typically seen during HS were decreased through HA. The representative TJ proteins including ZO-1, E-cadherin, and JAM-1 were found to be significantly down-regulated by HS, but sustained following HA. The ultrastructure of TJ was examined by TEM, which confirmed its protective effect on the intestinal barrier protection following HA. We also demonstrated that HA raised the intestinal levels of beneficial bacteria Lactobacillus and lowered those of the harmful bacteria Streptococcus through 16S rRNA gene sequencing. These findings suggest that HA with ORSP was proven to improve intestinal thermotolerance and the levels of protective gut microbiota against HS.

show abstract

Section: Methodsmentioning

confidence: 99%

Heat acclimation with probiotics-based ORS supplementation alleviates heat stroke-induced multiple organ dysfunction via improving intestinal thermotolerance and modulating gut microbiota in rats

Li,

Chen,

Wang

et al. 2024

Front. Microbiol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The HA protocol was conducted according to previously reported protocols used by our group, as well as recent advances in HA study (Cao et al, 2022;Huang et al, 2023;Li et al, 2023). Briefly, rats in the HA group were placed in an artificial climate chamber Shanghai Drawell Scientific Instrument Co.,Ltd.,Shanghai,China) where environmental parameters were maintained at 36 ± 1°C and 55 ± 5% RH for 2 h per day, for 21 days.…”

Section: Heat Acclimation and Heat Stroke Protocolsmentioning

confidence: 99%

Data_Sheet_1.ZIP

View full text Add to dashboard Cite

Unleashing the Neurotherapeutic Potential: The Crucial Role of miR-206-3p in Facilitating Hsp90aa1-Mediated Central Nervous System Injuries During Heat Stroke

Lei,

Yiming,

Qiang

et al. 2024

Mol Neurobiol

View full text Add to dashboard Cite

Acquired heat acclimation in rats subjected to physical exercise under environmental heat stress alleviates brain injury caused by exertional heat stroke

Cited by 4 publications

References 48 publications

Heat acclimation with probiotics-based ORS supplementation alleviates heat stroke-induced multiple organ dysfunction via improving intestinal thermotolerance and modulating gut microbiota in rats

Heat acclimation with probiotics-based ORS supplementation alleviates heat stroke-induced multiple organ dysfunction via improving intestinal thermotolerance and modulating gut microbiota in rats

Data_Sheet_1.ZIP

Unleashing the Neurotherapeutic Potential: The Crucial Role of miR-206-3p in Facilitating Hsp90aa1-Mediated Central Nervous System Injuries During Heat Stroke

Contact Info

Product

Resources

About