Acquired hemophilia A in a patient with hepatocellular carcinoma: a case report and literature review

Franco-Moreno, Ana Isabel; Santero-García, M.; Cabezón-Gutiérrez, Luis; Martin-Díaz, Rosa M.; García-Navarro, María José

doi:10.1007/s00277-016-2825-5

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…Even so, few studies have reported that a solid cancer is associated with a low specific risk of thrombosis, due to detailed associated mechanisms, such as acquired hemophilia [38] or acquired von Willebrand disease [39]. Our study indicates that the lack of thrombosis risk in a solid cancer could be due to a deficiency in the storage pool.…”

Section: Discussionmentioning

confidence: 65%

Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets

et al. 2021

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Venous thrombo-embolism (VTE) disease is the second most common cause of mortality in cancer patients, and evaluation and prevention of thrombosis risk is essential. VTE-associated risk varies according to the type of tumor disease. Oral cancer is the most frequent type of head and neck cancer, and it represents approximately 2.1% of all cancers worldwide. Most tumors are squamous cell carcinomas and are mainly due to tobacco and alcohol abuse. VTE risk associated with oral squamous cell carcinoma (OSCC) is low. However, many studies have shown that OSCC has the following biological features of cancers associated with a high thrombosis risk: modified thrombosis and fibrinolysis mechanisms; strong expression of procoagulant proteins; secretion of procoagulant microparticles; and production of procoagulant cytokines. Using an original mouse model of tongue squamous cell carcinoma, our study aimed to clarify this paradoxical situation. First, we showed that OSCC tumors have a pro-aggregatory phenotype and a high local thrombosis risk. Second, we found that tongue tumor mice do not have an elevated systemic thrombosis risk (the risk of an “at distance” thrombosis event such as lower extremity deep venous thrombosis or pulmonary embolism) and even show a reduction in risk. Third, we demonstrated that tongue tumor mice show a reduction in platelet reactivity, which explains the low systemic thrombosis risk. Finally, we found that tongue tumor mice present granule pool deficiency, thereby explaining the reduction in platelet reactivity and systemic thrombosis risk.

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Section: Discussionmentioning

confidence: 65%

Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets

et al. 2021

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“…Previous studies identified acquired vitamin K-dependent coagulation factor deficiency as a cause of bleeding in patients, and they indicated steroid pulse therapy as a treatment [[16], [17], [18]]. In addition, immunosuppressive drugs have a positive effect on acquired inhibitors of coagulation factors, which were associated with gastroenterological cancer [[19], [20], [21], [22], [23], [24]], and there are also a number of reports describing the benefits of steroid pulse therapy for specific autoimmune diseases [[25], [26], [27], [28]]. Admittedly, we hesitated to undertake the treatment because this patient had a high fever with a suspicious infection after the second surgery.…”

Section: Discussionmentioning

confidence: 99%

Dramatic decreases of all haemorrhagic coagulation factors by acquired inhibitors after extended left lobectomy

Sakuraoka

Suzuki

Mtsumoto

et al. 2019

International Journal of Surgery Case Reports

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“…There were 3 cases of gastric cancer[ 16 - 18 ] and 2 cases of HCC[ 19 , 20 ]. Another case report for AHA with HCC has also been published[ 21 ]. Compared with the patients with idiopathic AHA, patients with cancer are more likely to show recurrent bleeding and are less likely to achieve a complete response with eradication of the inhibitors[ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Acquired hemophilia A in solid cancer: Two case reports and review of the literature

Saito¹,

Ogasawara²,

Izumiyama³

et al. 2018

WJCC

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Acquired hemophilia A (AHA) is a rare, hemorrhagic autoimmune disease, whose pathogenesis involves reduced coagulation factor VIII (FVIII) activity related to the appearance of inhibitors against FVIII. Common etiological factors include autoimmune diseases, malignancy, and pregnancy. We report two cases of AHA in solid cancer. The first case is a 63-year-old man who developed peritoneal and intestinal bleeding after gastrectomy for gastric cancer. He was diagnosed with AHA, and was treated with prednisone, followed by cyclophosphamide. In the second case, a 68-year-old man developed a subcutaneous hemorrhage. He was diagnosed with AHA in hepatocellular carcinoma on CT imaging, and treated with rituximab alone. Hemostasis was achieved for both patients without bypassing agents as the amount of inhibitors was reduced and eradicated. However, both patients died within 1 year due to cancer progression. Successful treatment for AHA in solid cancer can be difficult because treatment of the underlying malignancy is also required.

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Acquired hemophilia A in a patient with hepatocellular carcinoma: a case report and literature review

Cited by 6 publications

References 10 publications

Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets

Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets

Dramatic decreases of all haemorrhagic coagulation factors by acquired inhibitors after extended left lobectomy

Acquired hemophilia A in solid cancer: Two case reports and review of the literature

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