Acquired hyperplastic gastric polyps in solid organ transplant patients

Amaro, Rafael; Neff, Guy; Karnam, Umaprasanna S; Tzakis, Andreas G.; Raskin, Jeffrey B.

doi:10.1111/j.1572-0241.2002.05975.x

Cited by 23 publications

(12 citation statements)

References 20 publications

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“…Neither Helicobacter pylori nor chronic active gastritis/intestinal metaplasia were identified in any of the 10 cases, and CMV serologies were negative in nine patients. 3 Similarly, we found no evidence of Helicobacter pylori by Genta/argyrophile stains in any patient. Evidence of CMV infection was seen in only two of 16 patients (12%; one positive only on culture and histologically occult) representing a higher Gastric hyperplastic polyps KD Jewell et al frequency than the 2% reported in all patients, 4 (and likely an artifact of small sample size).…”

Section: Discussionmentioning

confidence: 72%

“…The estimated incidence is less than 1%, and hyperplastic polyps are the most common. 2,5,[11][12][13] The development of gastric hyperplastic polyps in recipients of solid organ transplants has been recently described by Amaro et al 3 In their study, 10 solid organ transplant recipients (seven men, three women, 61 years median age) with hyperplastic polyps were examined. Notably hyperplastic polyps in these cases were more often multiple, involving the atrium and lacking neoplastic change.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 An uncommon occurrence in the general population, the development of gastric hyperplastic polyps in the solid organ transplant recipient recently has been described. 3 Hyperplastic polyp is one of the most common gastric epithelial polyps. Although its pathogenesis remains unclear, it is associated with chronic gastritis and Helicobacter pylori infection.…”

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confidence: 99%

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Gastric hyperplastic polyps in post transplant patients: a clinicopathologic study

et al. 2008

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Gastric hyperplastic polyps in organ transplant recipients have been recently described; however, the clinical significance of hyperplastic polyps in this setting remains unclear. The aim of this study is to further characterize the clinical presentation and histopathology of gastric hyperplastic polyps in organ transplant recipients as compared to hyperplastic polyps in non-transplant individuals. All gastric hyperplastic polyps diagnosed in our institute from 1999 to 2005 were retrieved. Clinical data including endoscopic findings were reviewed. Twenty cases without history of transplantation were randomly selected for a control population. Hematoxylin and eosin and Genta stains were reviewed. 104 cases of gastric hyperplastic polyps were identified. Sixteen (15%) had a history of solid organ (one liver/kidney, four livers, one lung, one kidney, one kidney/pancreas, three hearts) or bone marrow transplantation (five). The average time after transplantation was 28 months. Signs/symptoms leading to endoscopy were more frequently nausea/vomiting in transplant patients as compared to bleeding/hematemesis/anemia in non-transplant patients. The transplant patients tended to be younger with a reversed M:F ratio, but age was the only demographic factor that was statistically significant. There was no difference in polyp size, location and number. Histologically, no difference was observed in the frequency of active inflammation, Helicobacter pylori infection or intestinal metaplasia. Dysplasia was not present in any of the cases. None of the patients had a history of polyposis syndrome. In conclusion, a significant percentage of gastric hyperplastic polyps (15%) were from organ transplant patients, further suggesting a strong association of gastric hyperplastic polyps with transplantation. The younger age in the transplant group may be explained by the nature of the cohort qualified for transplantation. While no statistically significant differences in histopathologic features were found between transplant and nontransplant groups, analysis was limited by small case numbers. Overall, gastric hyperplastic polyps in the post transplant setting is a common, but under-recognized entity and merits further clinicopathologic analysis.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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Gastric hyperplastic polyps in post transplant patients: a clinicopathologic study

et al. 2008

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“…Another interesting observation is the development of hyperplastic gastric polyps in patients who undergo solid organ transplantation and immunosuppressive therapy. The association of these polyps with the immunosuppressive therapy has not yet been well established [5].Our patient was not exposed to any immunosuppressive therapy and did not undergo any organ transplant. Gastric polyps can be broadly defined as luminal lesions projecting above the plane of the mucosal surface.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Gastric Polyposis: A Rare Case Report

Powar¹,

Kanbarkar²

2017

IOSR JDMS

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“…However, not all hyperplastic polyps are associated with documented H. pylori infection, and there are no data demonstrating regression of hyperplastic polyps greater than 1 cm in diameter after H. pylori treatment. Less common associations include autoimmune gastritis, environmental gastritis, chemical gastropathy, ZollingerEllison syndrome, cytomegalovirus gastritis, amyloidopathy, gastric antral vascular ectasia, post-antrectomy stomach [46] , and post solid organ transplant recipients [47,48] . A hyperreparative process in response to these tissue insults gives hyperplastic polyps their characteristic histological features.…”

Section: B Amentioning

confidence: 99%

Intermittent gastric outlet obstruction caused by a prolapsing antral gastric polyp

Parikh

Kelley²,

Rendón³

et al. 2010

WJGO

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Most gastric polyps have an asymptomatic presentation and are an incidental finding on upper endoscopy. Sym ptomatic presentations can range from an ulcerated polyp leading to anemia and occult bleed to complete gastric outlet obstruction. We report a case of an 89year old woman who presented with postprandial nausea and early satiety. Her upper endoscopy revealed a 2 cm pedunculated hyperplastic polyp arising from the antrum of the stomach which was seen prolapsing into the pylorus causing intermittent gastric outlet obstruction. In the present report, we statistically analyzed 39 prolapsing gastric polyps previously reported in the English literature and demonstrate the current utility of monopolar snare polypectomy in establishing a histological diagnosis while offering simultaneous treatment. Additionally, we review the literature for the management of all hyperplastic gastric polyps in relation to advancements in digestive endoscopy.

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Acquired hyperplastic gastric polyps in solid organ transplant patients

Cited by 23 publications

References 20 publications

Gastric hyperplastic polyps in post transplant patients: a clinicopathologic study

Gastric hyperplastic polyps in post transplant patients: a clinicopathologic study

Diffuse Gastric Polyposis: A Rare Case Report

Intermittent gastric outlet obstruction caused by a prolapsing antral gastric polyp

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