Acquired night blindness due to rod dysfunction after long-term hemodialysis

Ueno, Shinji; Okado, Satoshi

doi:10.1007/s10384-021-00883-z

Cited by 1 publication

(1 citation statement)

References 34 publications

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“…These factors were not highly correlated with age and other explanatory variables considering the VIF, therefore we believe that they are independent factors that were significantly correlated with the flicker ERGs. The BUN level and Cre level are related to renal function, and they have been reported to be associated with slightly reduced 30-Hz flicker ERGs after long-term hemodialysis [ 36 ]. A significant correlation between chronic kidney disease and age-related macular degeneration has also been reported [ 37 – 39 ], and some reports suggested that drusen, the precursor of age-related macular degeneration, may have the same composition as glomerular deposits [ 40 – 42 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of factors affecting flicker ERGs recorded with RETeval from data obtained from health checkup screening

et al. 2023

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Purpose To determine the factors significantly associated with the amplitudes and implicit times of the flicker electroretinograms (ERGs) recorded with the RETeval system by analyzing the comprehensive data obtained during a health checkup screening. Methods Flicker ERGs were recorded with the RETeval system from 373 individuals who had a normal fundus and optical coherence tomography images. The sex, age, anthropometric, ophthalmologic, and hematologic data were collected from all participants who were 40- to 89-years-of-age. Univariable and multivariable linear mixed effects regression analyses were performed to identify factors that were significantly associated with the implicit times and amplitudes of the RETeval flicker ERGs. Results Univariable linear mixed effects regression analysis showed significant correlations between the implicit times and the best-corrected visual acuity, the age, the axial length, the blood sugar level, and the blood urea nitrogen level. Analyses by multivariable linear mixed effects regression identified that the axial length (β = 0.28), the age (β = 0.24), and the blood sugar level (β = 0.092) were three independent factors that were significantly correlated with the implicit times of the RETeval flicker ERGs. Univariable linear mixed effects regression analysis also showed significant correlations between the amplitudes of the RETeval flicker ERGs and the age, the platelet count, and the creatinine level. Multivariable linear mixed effects regression models identified the age (β = -0.092), the platelet count (β = 0.099), and the creatinine level (β = -0.12) as three independent factors that were significantly correlated with the amplitudes of the RETeval flicker ERGs. However, the smoking habits, body mass index, and the blood pressure were not significantly correlated with either the implicit times or amplitudes of the RETeval flicker ERGs. Conclusions Our results indicate that the age and some ophthalmologic and hematologic findings but not the anthropometric findings were significantly associated with the implicit times and amplitudes of the RETeval flicker ERGs. Thus, clinicians should remember these factors when analyzing the RETeval flicker ERGs.

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