Acquired Oral Microflora of Newborns During the First 48 Hours of Life

Rosenblatt, Rich; Steinberg, Doron; Mankuta, David; Zini, Avraham

doi:10.17796/1053-4628-39.5.442

Cited by 19 publications

(20 citation statements)

References 20 publications

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“…These findings were in line with previous literature showing the neonatal oral cavity microbiota mainly to consist of Lactobacillus, Streptococcus and Propionibacterium [9,32]. The neonatal oral cavity microbiota composition has previously been reported to be highly variable and significantly affected by the birth mode [8,10,33,34]. Vaginally born neonates have been observed to exhibit higher levels of Streptococcus salivarius, Lactobacillus curvata, Lactobacillus salivarius and Lactobacillus casei when compared to neonates born by caesarean section [35].…”

Section: Discussionsupporting

confidence: 91%

Composition and maternal origin of the neonatal oral cavity microbiota

Tuominen

Collado

Rautava

et al. 2019

Journal of Oral Microbiology

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Background: The origin of the initial oral microbiota in neonates still remains poorly understood. Objective: The aim of this study was to understand how the maternal microbiota contributes to the initial neonatal oral microbiota. Design: Twelve mother-neonate pairs with samples from the maternal oral mucosa, uterine cervix and placenta and the neonatal oral cavity immediately after birth were studied. The microbiota composition and diversity were characterized by 16S rRNA gene sequencing (V3-V4 region). The microbiota analyses and comparisons were carried out with Calypso software version 8.1 and with SourceTracker 1.0.1. Results: Samples from the neonatal oral cavity showed moderately high bacterial diversity and low richness. The neonatal oral cavity microbiota seems to share features mainly with the microbes detected in the placenta, followed by the cervical microbiota and the maternal oral microbiota. No statistically significant differences in diversity (Shannon index, p = 0.14), richness (Chao1, p = 0.53) or in microbial composition were observed according to delivery mode. Conclusion: The neonatal oral cavity microbiota is not significantly modulated by the birth canal or maternal oral microbiota but displays clear associations with microbes in the placenta. These results suggest that the neonatal oral microbiota may have a prenatal origin.

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Section: Discussionsupporting

confidence: 91%

Composition and maternal origin of the neonatal oral cavity microbiota

Tuominen

Collado

Rautava

et al. 2019

Journal of Oral Microbiology

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“…Finally, oral care with sterile saline did not change oral flora colonization among high‐risk newborns at early period of life. Although some researchers have suggested the benefits of early oral care for healthy full‐term newborns shortly after birth (Rosenblatt et al, ), we found that oral flora in NICU newborns is quite limited and questioned if oral care can change any normal process of flora colonization in the newborns. Furthermore, a recent study of healthy newborns born by cesarean delivery supports the benefit of exposure to microbials in the maternal vagina (Khoruts, ).…”

Section: Discussionmentioning

confidence: 68%

“…As newborns' sterile oral ecosystems come into contact with contaminated environments, flora may adhere to the inside of the mouth, particularly when teeth have yet to erupt. For healthy newborns, the epithelial binding sites for flora are known to reach adult levels within a few days of life, accelerated by oral activities, such as sucking and crying (Rosenblatt, Steinberg, Mankuta, & Zini, 2015). Oral activity for high-risk newborns and During the early days of life, the deformed oral epithelium of high-risk newborns seems to impair the colonization of flora.…”

Section: Discussionmentioning

confidence: 99%

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Flora colonization and oral care in high‐risk newborns

Ahn

Jun

Kim

et al. 2019

Specialist Pediatric Nursing

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Purpose A randomized intervention study was conducted to explore the impact of oral care with sterile normal saline to oral flora colonization of high‐risk newborns at the third day after birth. Design and Methods Ninety‐two newborns were allocated to either intervention or control group. After obtaining oral secretion for prepoint data, the intervention group received oral care with sterile normal saline only. Oral secretions for postpoint data were obtained 8 hr after the prepoint. Total 179 specimens were obtained during the study period. Results Among the total 92 newborns, 44.6% were female and 57.6% were premature. Mean gestational age and weight was 35.9 ± 3.2 weeks and 2,545 ± 697.5 g. The most common colonized flora included Streptococcus (26.3%), methicillin‐resistant Staphylococcus aureus (MRSA, 16.2%), and coagulase‐negative Staphylococci (CNS, 13.4%). The oral care with normal saline did not change the number of flora type of newborns. The statistic results were not significant by group (F = 0.918, p = 0.514), time (F = 0.322, p = 0.672), and the interaction between time and group (F = 0.519, p = 0.472). Practice Implications Oral care with sterile saline did not change oral flora colonization among high‐risk newborns at early period of life. This intervention can be safely delivered to high‐risk newborns when they are at risk of infection and particularly breast milk is not available.

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“…Owen OW described that it was the first microorganism which was responsible for dental caries development 29 . The oral cavity is free from microbes at the time of birth; the colonization occurs after some time 30 .…”

Section: History Of Lactobacillus In the Oral Cavitymentioning

confidence: 99%

Untitled

2019

IJPSR

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Dental caries is an infective serious transmittable bacterial disease characterized by a multi-factorial pathology. Main players in the etiology of this disease are cariogenic bacteria, fermentable carbohydrates, a susceptible tooth, the host, and the time. It is still one of the most common disease worldwide. Biological factor such as cariogenic bacteria plays an important role in dental caries initiation, progression as well as tooth decay. Previous studies suggested that the main pathogenic bacteria are Streptococcus mutans and Lactobacillus. Consequently, Lactobacillus is considered the second most cariogenic bacteria of oral flora. It is not the caries initiator but plays an important role in caries progression. Most of the previous studies were quantitative, so till now, researchers not know about the specific species of Lactobacillus which are directly associated with dental caries progression. Some species-level identification studies suggested that the most common Lactobacillus species are L. gasseeri, L. fermentum, L. vaginalis and L. casei which were predominantly reported at the most of the oral sites, i.e. saliva, tongue, carious lesion, dental plaque, etc. and maybe plays the main role in caries progression. The present review spotlights the role, pathogenicity of Lactobacillus in dental caries and their ecology in the oral cavity.

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Acquired Oral Microflora of Newborns During the First 48 Hours of Life

Cited by 19 publications

References 20 publications

Composition and maternal origin of the neonatal oral cavity microbiota

Composition and maternal origin of the neonatal oral cavity microbiota

Flora colonization and oral care in high‐risk newborns

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