Acquired Platelet Dysfunction with Eosinophilia (APDE) Syndrome: A Case Report

Abstract

Acquired platelet dysfunction with eosinophilia (APDE) is a syndrome which has transient state of platelet dysfunction in the presence of marked eosinophilia. This bleeding disorder, otherwise known as ''non-thrombocytopenic purpura with eosinophilia'', occurs commonly in children from South-East Asia. We report an 11 years old male child, who presented with ecchymotic patches over lower limbs, of recent onset. His hemogram revealed increased eosinophils with a normal platelet count. Coagulation screen revealed normal parameters except increase in bleeding time. Platelet aggregation studies showed normal platelet aggregation with ristocetin, reduced aggregation with ADP and no aggregation was seen with collagen.

Acquired Platelet Dysfunction with Eosinophilia

“…[5][6][7] The prognosis is generally good, with a benign clinical course, and resolves spontaneously within 3 to 6 months to about a year. 1,5 sTATEMENT Of AUTHORsHIP All authors certified fulfillment of ICMJE authorship criteria.…”

Diagnostic Testing Strategies to Manage COVID-19 Pandemic

“…APDE is a syndrome with transient state of platelet dysfunction mostly reported from children in Southeast Asia. 1 APDE requires the following features for diagnosis: clinical manifestation of spontaneous ecchymosis on the trunk or extremities; hemogram showing eosinophilia; and evidence of platelet dysfunction. 2 The spontaneous ecchymosis seen clinically is indistinguishable from that of idiopathic thrombocytopenic purpura (ITP).…”