Acquired reactive perforating collagenosis

Acquired Reactive Perforating Collagenosis: A Case Report

“…Almost always the lesions are pruritic, and new lesions appear followed by Koebner’s phenomenon. In our patient, a clinical polymorphism between APC and perforating folliculitis was observed, suggesting the possible overlap of perforating dermatosis, which is reported in the literature particularly in patients with chronic renal failure [ 12 , 13 ]. The histological study combined with Masson's trichrome stain shows a dome-shaped lesion with a central crater, focal epidermal ulceration, covered by a hyperkeratotic crust, and penetration of underlying dermal tissues through the dermoepidermal junction.…”

“…Once again, the overlap noted clinically was also raised histologically by Indian authors with the coexistence of the histological image of ARPC and perforating folliculitis [ 2 , 13 ]. Dermoscopy findings can also contribute to the diagnosis and reveal a red-brown structureless area covered with crusts and scales centrally, surrounded by a white rim, and a reddish inflammatory circle with peripheral vessels [ 12 , 14 ]. The treatment of perforating dermatoses is difficult.…”

Perforating Gout: Expanding the Differential for Transepidermal Elimination

“…Two large series [ 11 , 12 ] confirm renal disease to be by far the most common cause of perforating dermatosis, followed by diabetes and malignancy. Many case reports and smaller series of acquired perforating dermatoses were identified [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], again most commonly associated with renal disease and/or diabetes [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Associations with other systemic diseases have also been observed.…”

Unraveling the Enigma of Perforating Itches: A Comprehensive Report of Reactive Perforating Collagenosis in Three Patients

“…The lesion erupts as a papule and grows wider and deeper over one month, then a central crater develops with a compact horny plug appearance over the periphery of the lesion. This may regress over one month leaving behind a scar or hypo/hyperpigmented area [ 6 , 9 ]. This is associated with pruritis of varying degrees.…”

“…The usual clinical presentation of RPC is umbilicated, hyperkeratotic, millimetric, or large papules or nodules, with the presence of extensive crust formation. Skin biopsy and histopathological examination are essential for diagnosis [ 5 , 6 ]. This case report focuses on three distinct cases that were observed, highlighting the diverse manifestations of RPC.…”