Acquired Renal Cystic Disease After Liver Transplantation in Children

Franchi‐Abella, Stéphanie; Mourier, Olivia; Pariente, D.; Frank-Soltysiak, M.; Bernard, O.; Debray, D.

doi:10.1016/j.transproceed.2007.08.019

Cited by 18 publications

(20 citation statements)

References 5 publications

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“…CNIs are felt to be the principal cause of de novo posttransplant renal dysfunction and factor in the progression of renal disease . Acquired renal cystic disease may occur after transplantation . Renal lesions have been associated with moderate renal dysfunction, biopsy‐proven chronic liver graft rejection, and thrombosis of the retrohepatic vena cava .…”

Section: Immunosuppressionmentioning

confidence: 99%

“…Single-center studies suggest that renal function is stable for most pediatric LT recipients 1 to 5 years after transplantation [169][170][171][172][173][174][175][176][177][178][179][180][181][182][183][184][185][186] and that only a small subgroup develops progressive deterioration. In a recent multicenter, cross-sectional study of the measured GFR in 397 pediatric patients 1 or more years (mean 5 5.2 years) after LT, 17.6% had a measured GFR < 90 mL/ minute/1.73 m 2 .…”

Section: Prevalence and Riskmentioning

confidence: 99%

“…173,174 Acquired renal cystic disease may occur after transplantation. 175,176 Renal lesions have been associated with moderate renal dysfunction, biopsyproven chronic liver graft rejection, and thrombosis of the retrohepatic vena cava. 175 Cyclosporine A and renal dysfunction are associated with acquired cystic kidney disease.…”

Section: Prevalence and Riskmentioning

confidence: 99%

See 2 more Smart Citations

Long-term medical management of the pediatric patient after liver transplantation: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation

et al. 2013

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Section: Immunosuppressionmentioning

confidence: 99%

Section: Prevalence and Riskmentioning

confidence: 99%

See 1 more Smart Citation

Long-term medical management of the pediatric patient after liver transplantation: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation

et al. 2013

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“…Renal lesions of chronic CNI toxicity are not unique or specific but may include obliterative arteriolopathy, glomerular ischemic collapse, and scarring with focal areas of tubular atrophy and interstitial fibrosis (striped fibrosis) . Acquired renal cysts have been found in pediatric liver transplant patients and may be related to CNI‐induced CKD . Some have suggested improved renal function with the substitution of tacrolimus vs. cyclosporine based immunosuppression but such comparisons are difficult.…”

Section: Which Children With Liver Transplants Are At Most Risk For Ckd?mentioning

confidence: 99%

The kidney in pediatric liver transplantation: An updated perspective

Matloff

Arnon

Saland

2012

Pediatric Transplantation

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CKD continues to detract from the success of improved survival in pediatric liver transplantation, and its presence is likely under recognized. Here we review the literature regarding the prevalence, etiology, and management of renal dysfunction in pediatric liver transplant recipients. Long-term studies suggest the prevalence of CKD to be 25-38% by 5-10 yr post-transplant. While important, sole use of serum creatinine overestimates renal function in this population. Screening for and treatment of persistent proteinuria and hypertension as well as minimization of nephrotoxic insults are the mainstays to delay or prevent CKD progression. Office-based blood pressure measures are less sensitive than ABPM, which is specifically recommended by the American Heart Association for its ability to diagnose masked hypertension in pediatric liver transplant recipients. Long-term risk of CKD is predominantly secondary to CNI toxicity. CNI minimization protocols have shown promise in slowing progression of CKD while maintaining graft function, but large-scale randomized control trials with long-term follow-up are needed.

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“…Dans notre expérience personnelle, près de 40 % ont à 10 ans de la TH une diminution de la clairance plasmatique à l'ethylenediaminetetracetic acid 3), associés à une diminution de la clairance rénale ont été découverts fortuitement à l'examen tomodensitométrique des reins chez près de 30 % des 108 enfants explorés à 10 ans de la greffe [29]. Les indications de transplantation rénale secondaire restent encore exceptionnelles chez les adolescents (< 1 %).…”

Section: Insuffisance Rénale Chroniqueunclassified