2019
DOI: 10.1016/j.thromres.2019.10.012
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Acquired von Willebrand syndrome in patients on long-term left ventricular assist device support: Results of a Belgian center

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“…Second, we previously demonstrated that a murine anti-M monoclonal antibody could inhibit shear-induced VWF cleavage by ADAMTS13 in left ventricular assist devices in vitro and in vivo. 33 The availability of a fully human inhibitory anti-M antibody would facilitate its use in clinical trials. Of note, whether the higher prevalence of anti-M autoantibodies in the Japanese cohort compared with the mainly Caucasian cohorts could be because of the fact that Japanese patients with iTTP were diagnosed based on the presence of inhibitory autoantibodies or because of their difference in the genetic background, remains to be determined.…”
Section: Discussionmentioning
confidence: 99%
“…Second, we previously demonstrated that a murine anti-M monoclonal antibody could inhibit shear-induced VWF cleavage by ADAMTS13 in left ventricular assist devices in vitro and in vivo. 33 The availability of a fully human inhibitory anti-M antibody would facilitate its use in clinical trials. Of note, whether the higher prevalence of anti-M autoantibodies in the Japanese cohort compared with the mainly Caucasian cohorts could be because of the fact that Japanese patients with iTTP were diagnosed based on the presence of inhibitory autoantibodies or because of their difference in the genetic background, remains to be determined.…”
Section: Discussionmentioning
confidence: 99%