Acquisition and Long-term Carriage of Multidrug-Resistant Organisms in US International Travelers

Worby, Colin J.; Earl, Ashlee M.; Turbett, Sarah E; Becker, Margaret; Rao, Sowmya R.; Oliver, Elizabeth; Walker, Allison Taylor; Walters, Maroya Spalding; Kelly, Paul; Leung, Daniel T.; Knouse, Mark; Hagmann, Stefan; Ryan, Edward T.; LaRocque, Regina C.

doi:10.1093/ofid/ofaa543

Cited by 27 publications

(37 citation statements)

References 12 publications

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“…More recently, the Global TravEpiNet (GTEN) study prospectively screened stool of 608 U.S. international travelers for ESBL-PE, CPE and mcr -mediated colistin-resistant Enterobacterales (MCRE) before and after travel from November 2017 to April 2019 [ 22 ▪ , 42 ▪ – 44 ▪ ]. Travelers most commonly visited India, South Africa and Peru.…”

Section: Antimicrobial Resistance In Travelersmentioning

confidence: 99%

“…Travelers most commonly visited India, South Africa and Peru. Thirty-eight percent of returning travelers acquired ESBL-PE, of which most were E. coli ; CPE and MCRE were also detected independently and concomitantly with ESBL-PE [ 22 ▪ , 42 ▪ ]. There was a 30% carriage rate of acquired ESBL-PE at 3 months posttravel, and 10% at 1-year posttravel [ 22 ▪ ].…”

Section: Antimicrobial Resistance In Travelersmentioning

confidence: 99%

“…Antimicrobial usage, travelers’ diarrhea and destination have been repeatedly identified as risk factors for AMR bacterial acquisition during travel (Fig. 1 ) [ 22 ▪ , 26 , 29 ▪ , 37 ▪▪ , 41 ▪▪ , 45 ▪ ].…”

Section: Risk Factorsmentioning

confidence: 99%

“…The size of the shapes is a rough estimation of the relative importance of risk factors, based on the number of analyzed studies in which the risk factor was identified. The most common risk factor (destination) was identified in 13 out of 15 analyzed studies [ 22 ▪ , 26 , 28 , 29 ▪ , 30 , 32 , 35 ▪▪ , 36 , 37 ▪▪ , 38 ▪▪ , 41 ▪▪ , 50 ▪▪ , 55 ▪▪ , 56 ▪ , 81 ▪ ].…”

Section: Risk Factorsmentioning

confidence: 99%

“…International travel has been identified as playing a role in the spread of resistance genes and organisms [ 12 , 20 , 21 ▪ , 22 ▪ ]. The ongoing COVID-19 global pandemic has highlighted the ease with which infectious diseases can be disseminated by international travel.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial-resistant bacteria in international travelers

Sridhar

Turbett

Harris

et al. 2021

Current Opinion in Infectious Diseases

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Purpose of review Antimicrobial resistance (AMR) in bacteria poses a major risk to global public health, with many factors contributing to the observed increase in AMR. International travel is one recognized contributor. The purpose of this review is to summarize current knowledge regarding the acquisition, carriage and spread of AMR bacteria by international travelers. Recent findings Recent studies have highlighted that travel is an important risk factor for the acquisition of AMR bacteria, with approximately 30% of studied travelers returning with an acquired AMR bacterium. Epidemiological studies have shown there are three major risk factors for acquisition: travel destination, antimicrobial usage and travelers’ diarrhea (TD). Analyses have begun to illustrate the AMR genes that are acquired and spread by travelers, risk factors for acquisition and carriage of AMR bacteria, and local transmission of imported AMR organisms. Summary International travel is a contributor to the acquisition and dissemination of AMR organisms globally. Efforts to reduce the burden of AMR organisms should include a focus on international travelers. Routine genomic surveillance would further elucidate the role of international travel in the global spread of AMR bacteria.

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Section: Antimicrobial Resistance In Travelersmentioning

confidence: 99%