Acquisition of new genes by oral Neisseria.

Ison, Catherine; Glynn, A. A.; Bascomb, Shoshana

doi:10.1136/jcp.35.10.1153

Cited by 26 publications

(17 citation statements)

References 18 publications

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“…3d) suggests that aspartate can be deaminated to fumarate by aspartase, or transaminated to oxaloacetate with the production of glutamate by aminotransferase. Oral bacteria, such as Porphyromonas gingivalis, Prevotella interemedia, and some Neisseria species, are known to possess asparaginase (14,37), aspartase, and aminotransferase (28,32). β-Alanine is known to be produced by the carboxylation of aspartate (14), however no production was observed under the experimental conditions in the present study.…”

Section: Metabolome Analysis Of Intracellular Metabolites During Amincontrasting

confidence: 52%

Amino acid composition and amino acid-metabolic network in supragingival plaque

Washio¹,

Ogawa²,

Suzuki³

et al. 2016

Biomed. Res.

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Dental plaque metabolizes both carbohydrates and amino acids. The former can be degraded to acids mainly, while the latter can be degraded to various metabolites, including ammonia, acids and amines, and associated with acid-neutralization, oral malodor and tissue inflammation. However, amino acid metabolism in dental plaque is still unclear. This study aimed to elucidate what kinds of amino acids are available as metabolic substrates and how the amino acids are metabolized in supragingival plaque, by a metabolome analysis. Amino acids and the related metabolites in supragingival plaque were extracted and quantified comprehensively by CE-TOFMS. Plaque samples were also incubated with amino acids, and the amounts of ammonia and amino acid-related metabolites were measured. The concentration of glutamate was the highest in supragingival plaque, while the ammonia-production was the highest from glutamine. The obtained metabolome profile revealed that amino acids are degraded through various metabolic pathways, including deamination, decarboxylation and transamination and that these metabolic systems may link each other, as well as with carbohydrate metabolic pathways in dental plaque ecosystem. Moreover, glutamine and glutamate might be the main source of ammonia production, as well as arginine, and contribute to pH-homeostasis and counteraction to acid-induced demineralization in supragingival plaque.

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Section: Metabolome Analysis Of Intracellular Metabolites During Amincontrasting

confidence: 52%

Amino acid composition and amino acid-metabolic network in supragingival plaque

Washio¹,

Ogawa²,

Suzuki³

et al. 2016

Biomed. Res.

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“…This observation suggests a basis for the dissemination of tetM in vivo. Since other Neisseria species can acquire DNA from N. gonorrhoeae by transformation (17) or by conjugation (14), the possibility also exists that tetM will be acquired by these organisms as well.…”

Section: Discussionmentioning

confidence: 99%

High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant

Morse¹,

Johnson²,

Biddle³

et al. 1986

Antimicrob Agents Chemother

273

178

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Recently, strains of Neisseria gonorrhoeae have been isolated which are highly resistant to tetracycline (MICs of 16 to 64 micrograms/ml). This resistance was due to the acquisition of the resistance determinant tetM, a transposon-borne determinant initially found in the genus Streptococcus and more recently in Mycoplasma hominis, Ureaplasma urealyticum, and Gardnerella vaginalis. In N. gonorrhoeae, the tetM determinant was located on a 25.2-megadalton plasmid. This plasmid arose from the insertion of tetM into the 24.5-megadalton gonococcal conjugative plasmid. The tetM determinant could be transferred to suitable recipient strains of N. gonorrhoeae by both genetic transformation and conjugation.

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“…In recent years, several unusual strains of gram-negative, oxidase-positive diplococci have been isolated that are obviously neisserias but cannot be clearly identified as a recognized species (43,51,69). The strains isolated by these investigators exhibited characteristics of N. gonorrhoeae and N. meningitidis and in some cases could not be unequivocally assigned to either species (43,73).…”

Section: Mules Horses or Donkeysmentioning

confidence: 99%

Historical perspectives and identification of Neisseria and related species

Knapp

1988

Clin Microbiol Rev

119

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The pathogenic Neisseria spp., N. gonorrhoeae and N. meningitidis, have been studied extensively and rapid identification procedures have been designed to distinguish these species from the commensal Neisseria and related species that are normal flora of the oro- and nasopharynx. The commensal Neisseria spp. have been largely ignored except for isolated studies. It is important that we know about these species, however, because not only may some be misidentified as pathogenic species if identified with inappropriate procedures, but also they may occasionally be isolated from unusual sites and must be correctly identified to the species level for clinical purposes.

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Acquisition of new genes by oral Neisseria.

Cited by 26 publications

References 18 publications

<b>Amino acid composition and amino acid-metabolic network in supragingival </b><b>plaque </b>

<b>Amino acid composition and amino acid-metabolic network in supragingival </b><b>plaque </b>

High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant

Historical perspectives and identification of Neisseria and related species

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