Acquisition of nonmaternal Enterobacteriaceae by infants delivered in hospitals

Murono, K; Fuiita, Kozo; Yoshikawa, Mamoru; Saijo, Masayuki; Inyaku, F; Kakehashi, H; Tsukamoto, Teizo

doi:10.1016/s0022-3476(05)83504-8

Cited by 27 publications

(19 citation statements)

References 16 publications

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“…This high rate of enterobacteria colonization, particularly in the first days of life, was also described in initial studies that analyzed the microbiota colonization pattern of neonates living in developed countries (2,28). However, in later years, some authors have asserted that this initial enterobacteria predominance would have greatly declined in neonates living in developed countries (4,5,29,30).…”

Section: Discussionmentioning

confidence: 55%

“…In developed countries decades ago, the first facultative anaerobic colonizers were from the family Enterobacteriaceae , derived from the mother and the hospital environment (2,3). Recently, a shift from this pattern was observed and described as a diminished initial colonization by enterobacteria and high rates of colonization by Staphylococcus (4-6), which was probably derived from the skin of the parents (6).…”

Section: Introductionmentioning

confidence: 99%

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Establishment of the bacterial fecal community during the first month of life in Brazilian newborns

Brandt¹,

Taddei²,

Takagi³

et al. 2012

Clinics

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OBJECTIVE:The establishment of the intestinal microbiota in newborns is a critical period with possible long-term consequences for human health. In this research, the development of the fecal microbiota of a group of exclusively breastfed neonates living in low socio-economic conditions in the city of São Paulo, Brazil, during the first month of life, was studied.METHODS:Fecal samples were collected from ten neonates on the second, seventh, and 30th days after birth. One of the neonates underwent antibiotic therapy. Molecular techniques were used for analysis; DNA was extracted from the samples, and 16S rRNA libraries were sequenced and phylogenetically analyzed after construction. A real-time polymerase chain reaction (PCR) was performed on the samples taken from the 30th day to amplify DNA from Bifidobacterium sp.RESULTS:The primary phylogenetic groups identified in the samples were Escherichia and Clostridium. Staphylococcus was identified at a low rate. Bifidobacterium sp. was detected in all of the samples collected on the 30th day. In the child who received antibiotics, a reduction in anaerobes and Escherichia, which was associated with an overgrowth of Klebsiella, was observed throughout the experimental period.CONCLUSION:The observed pattern of Escherichia predominance and reduced Staphylococcus colonization is in contrast with the patterns observed in neonates living in developed countries.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Establishment of the bacterial fecal community during the first month of life in Brazilian newborns

Brandt¹,

Taddei²,

Takagi³

et al. 2012

Clinics

View full text Add to dashboard Cite

show abstract

“…After birth, the microbes from a mother’s mouth and skin and those of an environmental origin transfer horizontally to the newborn through several processes [13,26,27]. Moreover, frequent nosocomial intestinal acquisition of hospital strains of E. coli to neonates has been suggested using plasmid profiling [27].…”

Section: Influence Of Non-maternal Factors On the Establishment Of Bimentioning

confidence: 99%

“…Moreover, frequent nosocomial intestinal acquisition of hospital strains of E. coli to neonates has been suggested using plasmid profiling [27]. On the other hand, during birth through vaginal delivery, infants are first exposed to microbes that originate from the mother during the birthing process.…”

Section: Influence Of Non-maternal Factors On the Establishment Of Bimentioning

confidence: 99%

Influence of Maternal Bifidobacteria on the Development of Gut Bifidobacteria in Infants

2012

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Intestinal microbiota plays an important role in human health by influencing metabolic activities that result in the creation of energy and absorbable nutrients, a barrier to the colonization of pathogens, and stimulation of the immune system. The development of fecal microbiota in neonates is crucial because those bacteria are the first to colonize the sterile intestine of the neonates and, thus, have a significant effect on the host. Initial colonization is also relevant to the ﬁnal composition of the permanent microbiota in adults. Bifidobacteria are predominant in the fecal microbiota of infants, and, therefore, they are important to an understanding of how commensal bifidobacteria is established in the intestine of infants. While the mother’s bifidobacteria are considered to significantly influence the infant’s bifidobacteria, it is not clear whether a specific bifidobacterial strain transmits vertically from mother to infant and what factors of the mother before delivery influence the establishment of intestinal bifidobacteria in infants. This review focuses on the impact of maternal bifidobacteria on the development of gut bifidobacteria in the infant and suggests that there is cumulative evidence regarding bifidobacterial transfer from the maternal gut or breast milk to the infant gut.

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“…Several studies have reported that, during and after birth, microbes from both the mother and surrounding environment colonize the gastrointestinal tract of the infant (13)(14)(15). The intestinal microbiota of infants born through a cesarean section is highly different from that of the neonates born through a vaginal delivery, indicating the significant role of motherto-infant transmission of intestinal and vaginal microbiota in the development of neonatal intestinal microbiota (16,17).…”

mentioning

confidence: 99%

Influence of Maternal Bifidobacteria on the Establishment of Bifidobacteria Colonizing the Gut in Infants

et al. 2009

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ABSTRACT:The aim of this study was to examine the influence of maternal intestinal and vaginal bifidobacteria on the establishment of bifidobacteria colonizing the gut in infants. Fecal samples from 110 healthy pregnant mothers within 1 mo before delivery and their babies at 1 mo of age and 100 vaginal swabs from the mother within 7 d before delivery were collected at a maternity hospital in Fukuoka city, Japan. The fecal and vaginal samples were assayed by PCR to detect Bifidobacterium species and by real-time PCR assays to estimate the bifidobacterial number. The detection of Bifidobacterium breve in the mothers' feces was significantly associated with increases in both the bifidobacterial counts and number of Bifidobacterium species in the babies' feces. In addition, a cesarean section was significantly associated with both a decrease in the counts and diversity of bifidobacteria in the babies' feces. The number of Bifidobacterium species detected in the vaginal swabs of mothers were not associated with either the bifidobacterial counts or the diversity of bifidobacteria in the babies' feces. The most important determinants of intestinal bifidobacteria in infants were the colonization of B. breve in the mothers' gut and vaginal delivery.

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Acquisition of nonmaternal Enterobacteriaceae by infants delivered in hospitals

Cited by 27 publications

References 16 publications

Establishment of the bacterial fecal community during the first month of life in Brazilian newborns

Establishment of the bacterial fecal community during the first month of life in Brazilian newborns

Influence of Maternal Bifidobacteria on the Development of Gut Bifidobacteria in Infants

Influence of Maternal Bifidobacteria on the Establishment of Bifidobacteria Colonizing the Gut in Infants

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