Acquisition of social behavior in mammalian lineages is related with duplication events of FPR genes

Silva, Liliana; Mendes, Tito; Antunes, Agostinho

doi:10.1016/j.ygeno.2020.03.015

Cited by 4 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Formyl peptide receptor (FPR) family was firstly detected in immune cells (Le et al 2002; Silva et al 2020) and it has also been reported as a third family of VNRs in mice (Liberles et al 2009; Rivière et al 2009) with up to 12 FPR genes, including 6 pseudogenes, exclusively observed in mice vomeronasal tissue extracts -the families Fpr-rs1, Fprrs3, Fpr-rs4, Fpr-rs6 and Fpr-rs7-. However, the only two FPR genes found in the rabbit vomeronasal organ transcriptome were FPR1 and FPR2 -also called Fpr-rs2– and were not transcribed in mouse vomeronasal neurons (Rivière et al 2009), but in other cell types and tissues more closely related to immunity (Migeotte et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Section: B) Formyl Peptide Receptorsmentioning

confidence: 99%

See 1 more Smart Citation

A comprehensive analysis of vomeronasal organ transcriptome reveals variable gene expression depending on age and function in rabbits

Villamayor¹,

Robledo

Fernandez³

et al. 2020

Preprint

View full text Add to dashboard Cite

The vomeronasal organ (VNO) is a chemosensory organ specialized in the detection of pheromones and consequently the regulation of behavioural responses mostly related to reproduction. VNO shows a broad variation on its organization, functionality and gene expression in vertebrates, and although the species analyzed to date have shown very specific features, its expression patterns have only been well-characterized in mice. Despite rabbits represent a model of chemocommunication, unfortunately no genomic studies have been performed on VNO of this species to date. The capacity of VNO to detect a great variety of different stimuli suggests a large number of genes with complex organization to support this function. Here we provide the first comprehensive gene expression analysis of the rabbit VNO through RNA-seq across different sexual maturation stages. We characterized the VNO transcriptome, updating the number of the two main vomeronasal receptor (VR) families, 129 V1R and 70 V2R. Among others, the expression of transient receptor potential channel 2 (TRPC2), a crucial cation channel generating electrical responses to sensory stimulation in vomeronasal neurons, along with the specific expression of some fomyl-peptide receptors and H2-Mv genes, both known to have specific roles in the VNO, revealed a the particular gene expression repertoire of this organ, but also its singularity in rabbits. Moreover, juvenile and adult VNO transcriptome showed consistent differences, which may indicate that these receptors are tuned to fulfill specific functions depending on maturation age. We also identified VNO-specific genes, including most VR and TRPC2, thus confirming their functional association with the VNO. Overall, these results represent the genomic baseline for future investigations which seek to understand the genetic basis of behavioural responses canalized through the VNO.HIGHLIGHTSFirst description of the rabbit vomeronasal organ (VNO) transcriptomeVNO contains a unique gene repertoire depending on the speciesHigh fluctuation of the VNO gene expression reveals changes dependent on age and specific functionsMost vomeronasal-receptors (VR) and transient receptor potential channel 2 (TRPC2) genes are VNO-specificReproduction-related genes shows a wide expression pattern

show abstract

Section: Discussionmentioning

confidence: 99%

Section: B) Formyl Peptide Receptorsmentioning

confidence: 99%

A comprehensive analysis of vomeronasal organ transcriptome reveals variable gene expression depending on age and function in rabbits

Villamayor¹,

Robledo

Fernandez³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Comparative genomics indicates that the retention or loss of specific vomeronasal receptors often aligns with the ecological and social structures of the species in question. For instance, species with more intricate social hierarchies or mating systems tend to possess a richer repertoire of functional VNRs [293]. Moreover, the transcriptome analysis of the VNO in mice under different physiological and environmental conditions showed notable variations in the expression of vomeronasal receptors even among individuals of the same species [256,294,295].…”

Section: Anatomy Of the Vomeronasal Organmentioning

confidence: 99%

Pheromone Sensing in Mammals: A Review of the Vomeronasal System

Torres,

Ortiz-Leal,

Sanchez-Quinteiro

2023

Anatomia

View full text Add to dashboard Cite

This review addresses the role of chemical communication in mammals, giving special attention to the vomeronasal system in pheromone-mediated interactions. The vomeronasal system influences many social and sexual behaviors, from reproduction to species recognition. Interestingly, this system shows greater evolutionary variability compared to the olfactory system, emphasizing its complex nature and the need for thorough research. The discussion starts with foundational concepts of chemocommunication, progressing to a detailed exploration of olfactory systems. The neuroanatomy of the vomeronasal system stands in contrast with that of the olfactory system. Further, the sensory part of the vomeronasal system, known as the vomeronasal organ, and the integration center of this information, called the accessory olfactory bulb, receive comprehensive coverage. Secondary projections of both the olfactory and vomeronasal systems receive attention, especially in relation to the dual olfactory hypothesis. The review concludes by examining the organization of the vomeronasal system in four distinct mammalian groups: rodents, marsupials, herpestids, and bovids. The aim is to highlight the unique morphofunctional differences resulting from the adaptive changes each group experienced.

show abstract

“…Comparative genomics indicate that the retention or loss of specific vomeronasal receptors often aligns with the ecological and social structures of the species in question. For instance, species with more intricate social hierarchies or mating systems tend to possess a richer repertoire of functional VNRs [271]. Moreover, the transcriptome analysis of the VNO in mice under different physiological and environmental conditions showed notable variations in the expression of vomeronasal receptors even among individuals of the same species [272][273][274].…”

Section: Anatomy Of the Vomeronasal Organmentioning

confidence: 99%

Pheromone Sensing in Mammals: A Review on the Vomeronasal System

Torres,

Ortiz-Leal,

Sanchez-Quinteiro

2023

Preprint

View full text Add to dashboard Cite

This review delves into the significance of chemical communication in mammals, with an emphasis on the role of the vomeronasal system in sensing pheromone-mediated interactions. The vomeronasal system shapes a variety of social and sexual behaviors, including reproduction, hierarchy formation, maternal bonding, and species recognition. Intriguingly, this system presents a vast degree of evolutionary variability, more so than variations observed in the olfactory system. This adaptive diversity underscores the challenges in studying the vomeronasal system, emphasizing the need for detailed research into its neuroanatomy and functional morphology. This review traverses an array of topics central to our understanding of chemical communication in mammals. We begin with the foundational role and basic concepts of chemocommunication. This is followed by an in-depth exploration of the olfactory systems. Subsequently, the neuroanatomical underpinnings of the vomeronasal system are juxtaposed against those of the olfactory system. Our focus then shifts to an exhaustive study of the sensory element of the vomeronasal system, the vomeronasal organ, and the integrating center of this information, the accessory olfactory bulb. The discussion extends to secondary projections of both the olfactory and vomeronasal systems in the light of the dual olfactory hypothesis. The review culminates with a detailed look at four specific models of vomeronasal system organization belonging to four evolutionarily distinct mammalian families: rodents, marsupials, herpestids, and bovids. These have been meticulously analyzed by the authors, aiming to spotlight the significant morphofunctional differences stemming from the adaptive changes imprinted on the system.

show abstract

Acquisition of social behavior in mammalian lineages is related with duplication events of FPR genes

Cited by 4 publications

References 40 publications

A comprehensive analysis of vomeronasal organ transcriptome reveals variable gene expression depending on age and function in rabbits

A comprehensive analysis of vomeronasal organ transcriptome reveals variable gene expression depending on age and function in rabbits

Pheromone Sensing in Mammals: A Review of the Vomeronasal System

Pheromone Sensing in Mammals: A Review on the Vomeronasal System

Contact Info

Product

Resources

About