Acral Cutaneous Neural Angiomatous Hamartoma: A Variant of Palmar Cutaneous Hamartoma?

Abstract

Hamartomas are benign malformations composed of tissue elements normally found at that site, but which are growing in a disorganized fashion. Cutaneous hamartomas containing only neural and/or neurovascular elements are very rare, with very few case reports in the literature. Herein we describe a case of congenital neural angiomatous hamartoma of the skin.

Multiple Craniofacial Nodules and Plaques Distributed Bilaterally Along Blaschko Lines

“…However, some studies have shown that these lesions may occasionally undergo malignant degeneration. In fact, several chromosomal and genetic defects have been identified in benign neoplasms, hamartomas, and malignant tumors …”

“…In fact, several chromosomal and genetic defects have been identified in benign neoplasms, hamartomas, and malignant tumors. [2][3][4] Most cases of hair follicle nevi present as solitary lesions. However, this patient had multiple craniofacial lesions distributed bilaterally along Blaschko lines in a segmental pattern, probably owing to a somatic point sequence variation.…”