Acral Lentiginous Melanoma: A Rare Variant With Unique Diagnostic Challenges

Brazen, Brett; Gray, DO Taylor; Farsi, DO Maheera; Miller, DO Richard

doi:10.7759/cureus.8424

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…In addition, surgical treatment is the primary effective treatment for patients with ALM. 38 In this study, the HR for patients who did not receive surgical treatment was more than 3.5%. Therefore, the nomogram prediction model in this study included not only the AJCC staging system, but also patient demographic characteristics and other clinical parameters.…”

Section: Discussionmentioning

confidence: 55%

Nomogram for Predicting Overall Survival in Acral Lentiginous Melanoma: A Population‐based Study

Yin

Zhao

Yang

et al. 2021

IJGM

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Background The objective of this study was to establish a nomogram for predicting the overall survival (OS) of patients with acral lentiginous melanoma (ALM). Materials and Methods The study sample was selected from 1785 patients diagnosed with ALM from 2004 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) database, and R software was used to divide patients into the training cohort and validation cohort at a ratio of 7: 3. Stepwise selection method in the Cox regression model was used in the training cohort to select predictive variables to construct the nomogram, and model validation parameters were used in the validation cohort to evaluate the performance of the nomogram. Results The nomogram showed that age at diagnosis had the greatest impact on OS in patients with ALM, followed by AJCC stage, surgical treatment, SEER stage, sex, race, and marital status. The index of concordance, area under the receiver operating characteristic curve, calibration plots, net reclassification improvement, integrated discrimination improvement, and decision curve analysis demonstrate the good performance of this nomogram. Conclusion The prognostic value of the nomogram is superior to that of the AJCC staging system alone, and it helps clinicians to better predict 3-, 5-, and 8-year OS in patients with ALM.

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Section: Discussionmentioning

confidence: 55%

Nomogram for Predicting Overall Survival in Acral Lentiginous Melanoma: A Population‐based Study

Yin

Zhao

Yang

et al. 2021

IJGM

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“…The prognosis for people with this type varies with disease stage and is typically poorer than with other melanoma subtypes. Patients with advanced ALM are being investigated for response to newer therapeutic modalities, including immunotherapies and targeted drugs, with some encouraging early findings [ 74 , 75 ].…”

Section: Skin Cancermentioning

confidence: 99%

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Hasan,

Nadaf,

Imran

et al. 2023

Mol Cancer

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Skin cancer is a global threat to the healthcare system and is estimated to incline tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is curable at an early stage, novel drug identification, clinical success, and drug resistance is another major challenge. To bridge the gap and bring effective treatment, it is important to understand the etiology of skin carcinoma, the mechanism of cell proliferation, factors affecting cell growth, and the mechanism of drug resistance. The current article focusses on understanding the structural diversity of skin cancers, treatments available till date including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgery, combination therapy, molecular targets associated with cancer growth and metastasis, and special emphasis on nanotechnology-based approaches for downregulating the deleterious disease. A detailed analysis with respect to types of nanoparticles and their scope in overcoming multidrug resistance as well as associated clinical trials has been discussed. Graphical Abstract

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“…Acral lentiginous melanoma is often misdiagnosed as benign acral nevi (Brazen et al, 2020). Then, when acral lentiginous melanoma is accurately diagnosed, the prognosis is often poor, with a 5-year survival rate of less than 50% in Black individuals (Davis et al, 2021).…”

Section: Clarifying Misconceptionsmentioning

confidence: 99%

“…In addition, understanding that the most common and dangerous form of skin cancer in Black individuals is acral lentiginous melanoma, which occurs on non-sun-exposed areas, teaching should stress that patients should examine all skin, not only sun-exposed, areas. Melanoma may occur on the palms of hands, between toes, on the soles of feet, on the groin, under the fingernails, on buccal mucosa of the mouth, and in the eyes (Brazen et al, 2020). Depending on the patient situation, full-body examination will require use of mirrors.…”

Section: Implications For Clinical Practicementioning

confidence: 99%

Skin Cancer in People of Color

Shue-McGuffin

Powers

2022

Journal of the Dermatology Nurses' Association

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People of color are at a lower risk for developing skin cancer; however, melanoma skin cancer in this population is associated with a high mortality rate. Misconceptions regarding skin cancer risk often delay treatment, contributing to negative outcomes. These misconceptions were evident in a nurse-practitioner-led project that was conducted at a Division I University to improve sun safety in female collegiate athletes, with a lack of sun safety knowledge noted among Black participants. Nurses and nurse practitioners have a pivotal role in preventing skin cancer in people of color. This article summarizes the project's findings and current literature to clarify misconceptions regarding skin cancer in people of color, specifically in Black individuals. Clinical information is provided to guide nurses and nurse practitioners in promoting awareness and early detection of skin cancer.

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Acral Lentiginous Melanoma: A Rare Variant With Unique Diagnostic Challenges

Abstract: Brazen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cited by 4 publications

References 10 publications

Nomogram for Predicting Overall Survival in Acral Lentiginous Melanoma: A Population‐based Study

Nomogram for Predicting Overall Survival in Acral Lentiginous Melanoma: A Population‐based Study

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Skin Cancer in People of Color

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