Acral lymphomatoid papulosis

Type D Lymphomatoid Papulosis: An uncommon Variant. A case report and review of the literature

“…Unless accompanied by systemic lymphoma, most patients have no constitutional symptoms. Unusual presentations described include localized forms being more frequently seen in children and young adults, pustulous variants, LyP variants affecting the mucosal membranes and hidroa-vacciniforme-like variants [9,11,14,16,[17][18][19][20]. Lesions heals spontaneously within 2-8 weeks, leaving a hypopigmented or hyperpigmented, depressed, oval, and varioliform scar, especially if the previous lesion was an ulcero-necrotic nodule [9,11,14,21].…”

Clinicopathologic challenge: acral lymphomatoid papulosis

“…Occasionally, vesicles, pustules, and ulcerations are present 2,3 . Each episode usually resolves in a few weeks to months, leaving atrophic scars 4 . All age groups may be affected, from children to elderly patients 3,5 .…”

“…In 2007, Sharma et al. reviewed the cases of regional LyP in the literature and determined that more than 90 patients had been reported up to that time, a number that now has expanded to more than 100 reported cases 2–4,6 …”

“…Clinicopathological correlation is important in distinguishing between these two entities. LyP classically presents with recurrent crops of self‐healing papulonodules, while ALCL typically presents as a single lesion 4 . In Type C LyP or ALCL, where sheets of cells are seen, anaplastic lymphoma kinase‐1 (ALK‐1) staining is routinely done.…”

“…Due to the small number of acral LyP cases described, it is unclear whether the prognosis is different than that of a generalized variant. Treatment is not always required; however, topical and intralesional steroids may aid in shortening the time to resolution 4 . One could also consider other therapeutic options, such as methotrexate, phototherapy, tetracyclines, bexarotene, or low‐dose interferon alpha‐2b in selected cases.…”