Acral lymphomatoid papulosis: Report of five cases, differential diagnosis, and review

Abstract

Acral lymphomatoid papulosis (a‐LyP) is a rare clinical variant of LyP whose diagnosis may be challenging. A case series of a‐LyP was studied clinically, histopathologically, immunohistochemically, and from molecular point of view. Including ours, 25 cases of a‐LyP have so far been reported. Clinically, a‐LyP may present as acral involvement exclusively, in combination with mucosal lesions, (in itself a rare presentation), or in association with conventional LyP. The age of presentation was slightly higher than that of conventional LyP (55 vs 45 years) and a male predominance has been observed, as usually reported. Histopathologically, no morphological differences exclusively from conventional LyP were observed. LyP types A and E were the main variants. We describe for the first time one case of type D a‐LyP. Acral LyP is a rare entity and correct diagnosis can only be reached with clinical and histopathological correlation, to avoid aggressive treatment of this indolent lymphoproliferative disorder.

Vesicular Lymphomatoid Papulosis With DUSP22-IRF4 Rearrangement on Chromosome 6p25.3: A Case Report

“…8,[12][13][14][15][16] Blistering is an unusual clinical presentation of cutaneous T-cell lymphomas with only a few cases being reported in MF, Sézary syndrome, LyP, HTLV-1-associated adult T-cell leukemia/lymphoma, and hydroa vacciniforme-like T-cell lymphoma. [17][18][19][20][21][22][23][24][25][26][27] Therefore, other common diseases with vesicular eruption, such as viral infection, drug eruption, and autoimmune bullous disease (AIBD) should be considered first. In this case, the negative direct and indirect immunofluorescence results excluded AIBD.…”

“…A few cases of vesicular/bullous LyP were reported (Table 2). [22][23][24][25][26][27] The pathological findings were mainly corresponding to their type of LyP, which comprised type A (2 cases), type A/B (1 case), and type E (2 cases). The skin lesions could be localized or could involve multiple areas, and all cases with follow-up information had recurrent disease.…”

Painful Palmoplantar Lesions Following Vaccination: Answer

“…a-LyP is a rare, probably under-diagnosed, variant of LyP with only 25 reported cases in the most extensive review. 1 It affects older patients contrarily to conventional LyP, but maintains male predilection. Three clinical presentations have been described, including exclusive acral affectation, associated with mucosal involvement or associated with usual LyP lesions.…”