Acral melanosis

Isolated Palmoplantar Lentiginosis

“…No nail changes. Post-inflammatoryhyperpigmentation 2 Hyperpigmented macules and patches over the area of preceding inflammatory dermatosis. None.…”

“…No contact history. Addison 2 Generalized brown “muddy” hyperpigmentation with prominence on the face, neck, palmar creases, and mucosal membranes. Postural hypotension, salt cravings, and vitiligo.…”

“…No associated abnormalities. Vitamin B12 deficiency 2 Diffused hyperpigmentation on the hands, feet, and buccal mucosa. Fatigue, anorexia, angular stomatitis, gastritis, and palpitations.…”

“… 1 Acral distribution of lentigines can be associated with several genetic or acquired conditions with or without systemic abnormalities. 2 Patients with acral lentigines usually have involvement of other body sites (such as lip lentigines in Peutz-Jeghers syndrome or Laugier-Hunziker syndromes). 3 , 4 This report describes a distinct case of lentigines predominately on the palms and soles with no involvement of other body sites.…”

New-Onset Solitary Black Lesion on the Heel

“…Drug-induced acral pigmentation is an adverse effect by the anticancer drugs hydroxyurea, busulfan, and cyclophosphamide that occurs in gravity-dependent areas such as the heels where there is increased drug deposition (Bhalla & Garg, 2018). Clinically, this presents as brown-to-black macules that are not easily removed by paring of the lesions as they are thought to be caused by direct stimulation of melanocytes or formation of drug–melanin complexes within the basal layer of the epidermis (Bhalla & Garg, 2018).…”