Acral verrucous malignant melanoma in an immunosuppressed patient after kidney transplantation

BRAF ‐mutated, acral verrucous melanoma successfully treated by dabrafenib plus trametinib combination therapy

“…1 To our knowledge, only two previous cases of AVM have been reported in the literature, both of which had naevoid characteristics of melanocytes. 2,3 Of these, only one case has been described as accompanied by pagetoid spread (PS), 2 and was completely consistent with the present case.…”

“…A variety of clinicopathological variants of melanoma other than Clark types have been reported, including verrucous or naevoid melanomas . To our knowledge, only two previous cases of AVM have been reported in the literature, both of which had naevoid characteristics of melanocytes . Of these, only one case has been described as accompanied by pagetoid spread (PS), and was completely consistent with the present case.…”

From Melanocyte to Metastatic Malignant Melanoma

“…In either case the general acceptance is that intermittent sun exposure is the most important factor. The list of risk factors in developing malignant melanoma is long and includes pale skin, blond or red hair, numerous freckles and tendency to burn and tan poorly (predominantly skin phototype 1–3) [26–28, 31], presence of more than 50 acquired (common, banal) nevi [32], more than five dysplastic (atypical, Clark's) nevi, large congenital nevi [33, 34], nevi larger than 6 mm [35], PUVA therapy, tendency to sunburn and tan poorly, use of tanning salons, Xeroderma pigmentosum, immunosuppression, chemical exposures, scars, Marjolin's ulcer [36–39], and genetic factors. In fact 8%–12% of malignant melanomas occur in a familial setting which may be related to mutations of the CDKN2A gene that encodes p16 and is linked to chromosome 9p21 [40, 41].…”