Acremonium sp.—a leucinostatin A producing endophyte of European yew (Taxus baccata)

Strobel, Gary A.; Torczynski, Richard M.; Bollon, Arthur P.

doi:10.1016/s0168-9452(97)00131-3

Cited by 90 publications

(48 citation statements)

References 18 publications

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“…The least active munumbicin, based on the comparative MIC values, appeared to be munumbicin D (Table 3). The fact that these compounds had such remarkable activity against plant-pathogenic fungi and at least one bacterium lends support to the notion that Streptomyces NRRL 30562, as an endophyte, may have some role to play in protecting the host plant from invading pathogens (Yang et al, 1994 ;Strobel et al, 1997). Since the munumbicins were so active against an array of plant-pathogenic fungi and at least one bacterium, a general disk screening test was applied to a series of human-pathogenic bacteria.…”

Section: Biological Activities Of the Munumbicinsmentioning

confidence: 93%

Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans a aThe GenBank accession number for the sequence determined in this work is AY127079.

et al. 2002

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Munumbicins A, B, C and D are newly described antibiotics with a wide spectrum of activity against many human as well as plant pathogenic fungi and bacteria, and a Plasmodium sp. These compounds were obtained from Streptomyces NRRL 3052, which is endophytic in the medicinal plant snakevine (Kennedia nigriscans), native to the Northern Territory of Australia. This endophyte was cultured, the broth was extracted with an organic solvent and the contents of the residue were purified by bioassay-guided HPLC. The major components were four functionalized peptides with masses of 1269 6, 1298 5, 1312 5 and 1326 5 Da. Numerous other related compounds possessing bioactivity, with differing masses, were also present in the culture broth extract in lower quantities. With few exceptions, the peptide portion of each component contained only the common amino acids threonine, aspartic acid (or asparagine), glutamic acid (or glutamine), valine and proline, in varying ratios. The munumbicins possessed widely differing biological activities depending upon the target organism. For instance, munumbicin B had an MIC of 2 5 µg ml N1 against a methicillin-resistant strain of Staphylococcus aureus, whereas munumbicin A was not active against this organism. In general, the munumbicins demonstrated activity against Gram-positive bacteria such as Bacillus anthracis and multidrug-resistant Mycobacterium tuberculosis. However, the most impressive biological activity of any of the munumbicins was that of munumbicin D against the malarial parasite Plasmodium falciparum, having an IC 50 of 4 5O0 07 ng ml N1 . This report also describes the potential of the munumbicins in medicine and agriculture.

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Section: Biological Activities Of the Munumbicinsmentioning

confidence: 93%

Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans a aThe GenBank accession number for the sequence determined in this work is AY127079.

et al. 2002

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“…Leucinostatin A production from Acremonium sp. isolated from Taxus baccata is found to be active against breast cancer (Strobel et al, 1997). Pseudomonas viridiflava is a fluorescent bacteria located within the tissues associated with the leaves of many grass species produces ecomycins which represent a family of novel lipopeptides.…”

Section: Natural Products From Bacterial Endophytesmentioning

confidence: 99%

Inside the Plants: Bacterial Endophytes and their Natural Products

Pandey¹,

Singh²,

Singh³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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“…Local population of Arunachal Pradesh use Taxus bark for preparing 'Namkin chay' and use as medicine [14]. Endophytes harboring yew plant around the world have been reported to produce taxol and other bioactive metabolites [16][17][18]. Studies on fungal endophytes colonizing Taxus plant from this mega biodiversity hotspot part of the world, however, have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial endophytic fungal assemblages inhabiting bark of Taxus baccata L. of Indo-Burma mega biodiversity hotspot

Tayung

Jha

2010

Indian J Microbiol

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Fungal endophytes were isolated from inner bark of Taxus baccata L., an important source of potent anticancer drug taxol. Bark samples were collected from two locations of Arunachal Pradesh, India, part of the IndoBurma mega biodiversity hotspot, during two seasons i.e. monsoon and winter. Altogether 77 fungal strains representing 18 genera were isolated from T. baccata bark during the present investigation. The colonizing frequency was recorded as 38.5% and the fungal community comprised of 78% of Hyphomycetes, 5.2% of Coelomycetes, 2.6% of Zygomycetes and Ascomycetes and 9.1% of sterile mycelia. Most common and frequently isolated genera were Fusarium, Penicillium and Aspergillus. Simpson and Shannon diversity indices indicated higher species diversity during monsoon than during winter seasons irrespective of the locations. The two locations harbored 5 to 37 endophyte species and the similarity index was low during winter and high during monsoon. Ethyl acetate extract of fermentation cultures of these fungi were tested for their antimicrobial activity against a panel of human pathogenic Gram-positive and Gram-negative bacteria and fungi. Fifteen fungal isolates out of the isolated strains displayed antimicrobial activity. An endophytic fungus, identifi ed as Fusarium sp. displayed signifi cant antimicrobial activity against all the test pathogens.

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Acremonium sp.—a leucinostatin A producing endophyte of European yew (Taxus baccata)

Cited by 90 publications

References 18 publications

Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans a aThe GenBank accession number for the sequence determined in this work is AY127079.

Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans a aThe GenBank accession number for the sequence determined in this work is AY127079.

Inside the Plants: Bacterial Endophytes and their Natural Products

Antimicrobial endophytic fungal assemblages inhabiting bark of Taxus baccata L. of Indo-Burma mega biodiversity hotspot

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