Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma

Osman, Hany; Elsahy, Deena; Saadatzadeh, M. Reza; Pollok, Karen E.; Yocom, Steven S.; Hattab, Eyas M.; Georges, Joseph; Cohen-Gadol, Aaron

doi:10.1016/j.wneu.2018.03.207

Cited by 27 publications

(18 citation statements)

References 47 publications

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“…Nevertheless, the search for new photosensitizers is also an active target for the development of PDT. Several works have reported the use of new compounds as promising photosensitizers [ 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 ]. From synthesized compounds based on previous structures to entirely new compounds, the research is in continuously update.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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Due to their physical and chemical characteristics, anthocyanins are amongst the most versatile groups of natural compounds. Such unique signature makes these compounds a focus in several different areas of research. Anthocyanins have well been reported as bioactive compounds in a myriad of health disorders such as cardiovascular diseases, cancer, and obesity, among others, due to their anti-inflammatory, antioxidant, anti-diabetic, anti-bacterial, and anti-proliferative capacities. Such a vast number of action mechanisms may be also due to the number of structurally different anthocyanins plus their related derivatives. In this review, we highlight the recent advances on the potential use of anthocyanins in biological systems with particular focus on their photoprotective properties. Topics such as skin aging and eye degenerative diseases, highly influenced by light, and the action of anthocyanins against such damages will be discussed. Photodynamic Therapy and the potential role of anthocyanins as novel photosensitizers will be also a central theme of this review.

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Section: Photodynamic Therapymentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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“…AO-based PDT and RDT has been advanced to clinical studies for the treatment of sarcomas (osteosarcomas and rhabdomyosarcomas) (1, 7, 12, 23, 25, 55), while its efficacy for brain tumors has been assessed only in preclinical studies. Osman et al investigated the efficacy of AO-based PDT of glioma cells in vitro (56). Treatment of cultured glioblastoma cells with AO at a concentration of 0.001 mg/mL followed by 10 or 30 min incubation with white unfiltered light from light-emitting diode bulbs demonstrated dramatic cytostatic and cytocidal effects and almost complete eradication of glioblastoma cells in 72 h (56).…”

Section: Resultsmentioning

confidence: 99%

“…Osman et al investigated the efficacy of AO-based PDT of glioma cells in vitro (56). Treatment of cultured glioblastoma cells with AO at a concentration of 0.001 mg/mL followed by 10 or 30 min incubation with white unfiltered light from light-emitting diode bulbs demonstrated dramatic cytostatic and cytocidal effects and almost complete eradication of glioblastoma cells in 72 h (56).…”

Section: Resultsmentioning

confidence: 99%

Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy

et al. 2019

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Introduction: Acridine orange (AO) was first extracted from coal tar in the late nineteenth century and was used as a fluorescent dye. In this paper, we review emergent research about novel applications of AO for fluorescence surgery and cancer therapy.Materials and methods: We performed a systematic search in the MEDLINE, PubMed, Cochrane library, Google Scholar, Embase, Web of Science, and Scopus database using combinations of the term “acridine orange” with the following: “surgical oncology,” “neuropathology,” “microsurgery,” “intraoperative fluorescence,” “confocal microscopy,” “pathology,” “endomicroscopy,” “guidance,” “fluorescence guidance,” “oncology,” “surgery,” “neurooncology,” and “photodynamic therapy.” Peer-reviewed articles published in English were included in this review. We have also scanned references for relevant articles.Results: We have reviewed studies on the various application of AO in microscopy, endomicroscopy, intraoperative fluorescence guidance, photodynamic therapy, sonodynamic therapy, radiodynamic therapy.Conclusion: Although the number of studies on the clinical use of AO is limited, pilot studies have demonstrated the safety and feasibility of its application as an intraoperative fluorescent dye and as a novel photo- and radio-sensitizator. Further clinical studies are necessary to more definitively assess the clinical benefit AO-based fluorescence guidance, therapy for sarcomas, and to establish feasibility of this new approach for the treatment of other tumor types.

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“…Other sensitizers also have been proved to be effective in PDT or SDT including acridine orange (AO) 108 , 109 , methylene blue (MB) 53 , 54 , IR780 110 , 111 , and hypocrellin B (HB) 55 , 56 .…”

Section: Sensitizers For Cancer Therapymentioning

confidence: 99%

Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies

Zheng

et al. 2021

Acta Pharmaceutica Sinica B

105

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Many sensitizers have not only photodynamic effects, but also sonodynamic effects. Therefore, the combination of sonodynamic therapy (SDT) and photodynamic therapy (PDT) using sensitizers for sono-photodynamic therapy (SPDT) provides alternative opportunities for clinical cancer therapy. Although significant advances have been made in synthesizing new sensitizers for SPDT, few of them are successfully applied in clinical settings. The anti-tumor effects of the sensitizers are restricted by the lack of tumor-targeting specificity, incapability in deep intratumoral delivery, and the deteriorating tumor microenvironment. The application of nanotechnology-based drug delivery systems (NDDSs) can solve the above shortcomings, thereby improving the SPDT efficacy. This review summarizes various sensitizers as sono/photosensitizers that can be further used in SPDT, and describes different strategies for enhancing tumor treatment by NDDSs, such as overcoming biological barriers, improving tumor-targeted delivery and intratumoral delivery, providing stimuli-responsive controlled-release characteristics, stimulating anti-tumor immunity, increasing oxygen supply, employing different therapeutic modalities, and combining diagnosis and treatment. The challenges and prospects for further development of intelligent sensitizers and translational NDDSs for SPDT are also discussed.

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Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma

Cited by 27 publications

References 47 publications

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy

Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies

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