Acridine orange fluorochrome in the study of normal and malignant epithelium of the uterine cervix

Kaplan, Leo; Masin, Francis; Masin, Marianna; Carleton, Rodney L.; Bertalanffy, Ludwig von

doi:10.1016/0002-9378(60)90068-5

Cited by 10 publications

(1 citation statement)

References 14 publications

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“…Nevertheless, the relative value of the method compared with the purely morphological approach using Papanicolaou's technique has been much debated. Thus T6rnberg, Westin, and Norlander (1960) and Elevitch and Brunson (1961) have emphasized the technical rapidity of the cytochemical method while results of equal accuracy to those obtained with the Papanicolaou method have been claimed by Dart and Turner (1959) and by Kaplan, Masin, Masin, Carleton, and von Bertalanffy (1960). It is clear that the cytochemical method yields satisfactory results only in the hands of a competent cytologist (Holland and Ackermann, 1961) but the employment of lower magnifications is a definite advantage to the microscopist as stated by Tornberg et al (1960).…”

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Diagnosis of preinvasive carcinoma of the uterine cervix

Meyer¹

1965

Journal of Clinical Pathology

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SYNOPSISThe changes occurring at the periphery of invasive cervical carcinomas have been studied in detail, with particular reference to the incidence of preinvasive carcinoma. The various criteria used in the cytological diagnosis of malignancy have been evaluated, and the implications of large cytological screening programmes are discussed in a brief review of the literature.In 1867 Beale illustrated exfoliated malignant epithelial cells while the entity of preinvasive carcinoma was probably first recognized by Williams (1888) and more clearly defined by Schauenstein (1908) although the term 'carcinoma in situ' was not introduced until 1932 by Broders. Exfoliative cytology was finally established as a routine diagnostic method in this field by the work of Papanicolaou and Traut (1943) and has been actively practised since then all over the world. Although Schottlaender and Kermauner (1912) showed histologically that precancerous changes were present at the margins of invasive carcinomas the validity of the concept of preinvasive carcinoma depends ultimately on clinical evidence (Petersen, 1955;Koss, Stewart, Foote, Jordan, Bader, and Day, 1963).The term 'preinvasive carcinoma' is used here as synonymous with 'carcinoma in situ' but a more recent concept termed 'dysplasia' has been introduced and currently finds great favour with American workers. The boundaries of the latter condition are ill-defined and the prognosis is uncertain but a proportion develop into preinvasive carcinoma (Stern, 1959) while many examples show regression

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confidence: 96%