Acridone-labeled DNA aptamer for the detection of biomolecules

Acridone is an attractive fluorescent molecule for use in DNA probes. Sensing molecule, which has acridone as a signaling moiety and DNA aptamer as a recognition moiety, was prepared by postsynthetic modification method. The fluorescence of this sensing molecule changed depending on the DNA structure and l-argininamide could be detected by this molecule. This strategy could provide a quencher-free aptamer beacon.

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Specific Amino Acid Sensing Using a Single Acridone-labeled DNA Aptamer

Ozaki

Hagiwara

Kuwahara

2012

Chemistry Letters

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Acridone-labeled DNA aptamer for the detection of biomolecules

Abstract: An acridone-labeled DNA aptamer was synthesized to produce an aptamer probe. This aptamer probe could detect a specific molecule based on conformational changes upon binding of the specific molecules and the quenching of acridone emission.

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Specific Amino Acid Sensing Using a Single Acridone-labeled DNA Aptamer

Specific Amino Acid Sensing Using a Single Acridone-labeled DNA Aptamer

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