Acro-Angiodermatitis of the Foot

Mali, J.W.H.; Kuiper, J. P.; Hamers, A. A.

doi:10.1001/archderm.1965.01600170031005

Cited by 123 publications

(42 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We believe that HFLL can be clinically and pathologically distinguished from (myo) fibroblastic and fibrohistiocytic lesions such as fibromatosis, nodular fasciitis, CD34 positive Kaposi-like diseases (acroangiodermatitis of Mali and Stewart-Bluefarb syndrome) (14), fibrous histiocytoma and its variants (15), pleomorphic hyalinizing angiectatic tumor of soft parts (16), and dermatofibrosarcoma protuberans (DFSP) because it is basically a lipomatous lesion with an abundant fatty component. Fibromatosis is characterized by uniform, bland myofibroblasts running in a purposeful direction with elongate vessels.…”

Section: Discussionmentioning

confidence: 99%

“…Sharing a common location of the distal lower extremity and similar morphologic characteristics (hemosiderin, spindled cells) with pseudo-Kaposi Mali (14) of the dermatopathology literature, HFLL is different in that it is subcutaneous rather than dermal and lacks superficial ulceration. The patients with HFLL are not known to have vascular insufficiency like those with pseudo-Kaposi lesions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hemosiderotic Fibrohistiocytic Lipomatous Lesion: Ten Cases of a Previously Undescribed Fatty Lesion of the Foot/ankle

2000

View full text Add to dashboard Cite

We address the clinicopathologic features of a previously undescribed heavily-pigmented spindle cell proliferation within a circumscribed benign lipomatous lesion that occurs mainly in the ankle region of older females. Patients with "lipoma with fibrohistiocytic proliferation" were retrieved from our files. Slides and clinical information were reviewed, and immunohistochemistry was performed (n ‫؍‬ 5). Ten patients with hemosiderotic fibrohistiocytic lipomatous lesions were identified. All cases demonstrated a well-circumscribed fatty lesion with random focal proliferations of plump, slightly pleomorphic spindled cells, scattered inflammatory cells, and abundant iron pigment. The spindled cells had vesicular nuclei with indistinct nucleoli; occasional hyperchromatism was observed. No nuclear cytoplasmic inclusions were identified. The spindled component had a reactive appearance. In most cases, the fatty component, with homogeneously sized adipocytes, predominated. The lesions occurred in the foot/ankle region (8/10, one each cheek and hand) of primarily females (8/10) with a mean age of 50.6 years (range 42-63 years), size of 7.7 cm (range 2.5-17 cm), and prior duration of 3.1 years. Seven of eight patients had a history of prior trauma. The spindled component was positive for vimentin, calponin, CD34, and occasionally KP-1 or lysozyme and negative for caldesmon, S100, and desmin. Follow-up on eight patients revealed four with recurrences or residual disease over three years, requiring re-excision. No cases metastasized or caused patient death (mean 12 years, range 1-23 years). We describe a predominantly fatty lesion that is hemosiderin rich with a "fibrohistiocytic" proliferation, composed of histiocytes, myofibroblasts, and C34-positive fibroblasts, which occurs predominantly in the ankle region of middle-aged females. We believe that this is a reactive process due to antecedent trauma, the inflammatory cells, hemosiderin, mixed spindled cells, and homogeneous non-neoplastic appearance of the fat. HFLL can be distinguished from previously described lesions. Correct identification of hemosiderotic fibrohistiocytic lipomatous lesion is important, as it may locally recur. A search for these lesions was initiated because one of the authors (JCF-S) had encountered in practice several circumscribed fatty lesions with a spindled proliferation that resembled fibrohistiocytic neoplasms. The overall features were unlike spindle cell lipoma or other lipomatous neoplasms and had too much fat as part of the lesion for other spindle cell tumors including fibrohistiocytic and myofibroblastic neoplasms. To our knowledge, there have been no previous reports of such an entity. These lesions were superficial, found mainly in the ankle region, and were primarily composed of fat. We considered the possibility that this lesion was neoplastic. However, it is unencapsulated and has homogenously sized adipocytes, similar to normal fat. Hemosiderotic fibrohistiocytic lipomatous lesion (HFLL) appears reactive, with its mixed spindled...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hemosiderotic Fibrohistiocytic Lipomatous Lesion: Ten Cases of a Previously Undescribed Fatty Lesion of the Foot/ankle

2000

View full text Add to dashboard Cite

show abstract

“…It can occur due to various vascular conditions such as chronic venous insufficiency, 1 congenital or acquired (traumatic or iatrogenic) arteriovenous fistulas, arteriovenous fistulas and syndromes such as the Prader-Labhart-Willi syndrome and Klippel-Trenaunay syndrome. [2][3][4][5] It is also described as being linked with amputation stumps, the use of poorly-fitting suction-type devices, or affecting patients with paralyzed extremities or congenital myopathy.…”

Section: Introductionmentioning

confidence: 99%

“…1 We describe a case of acroangiodermatitis on the sole of the foot, associated with chronic venous insufficiency of the corresponding leg, as evidenced by Doppler ultrasound examination, and with good response to treatment with the use of elastic compression bandages and leg elevation.…”

mentioning

confidence: 96%

“…Doppler ultrasound was also useful for determining the cause of the injury as chronic venous insufficiency (the socalled 'Mali syndrome'). 1 The treatment of this condition is barely discussed in the literature and depends on the nature of the underlying circulatory disturbance. In cases related to chronic venous insufficiency, the use of compression bandages can sometimes relieve symptoms.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Acroangiodermatite (pseudossarcoma de Kaposi): uma condição raramente reconhecida. Um caso na planta do pé associado a insuficiência venosa crônica

Pimentel

Cuzzi

Azeredo-Coutinho

et al. 2011

An. Bras. Dermatol.

View full text Add to dashboard Cite

A acroangiodermatite ou pseudossarcoma de Kaposi é entidade angioproliferativa incomum relacionada a insuficiência venosa crônica, fístulas arteriovenosas, membros paralisados, cotos de amputação, síndromes vasculares e condições trombóticas. Apresenta-se, em geral, como máculas, pápulas ou placas purpúricas no dorso dos pés (especialmente hálux) e maléolos. Relatamos um caso de acroangiodermatite afetando a região plantar, por dois anos sem diagnóstico, para o qual a coloração histológica por hematoxilina-eosina e a marcação imuno-histoquímica com CD34 foram decisivas. A paciente tinha insuficiência venosa crônica e a lesão respondeu bem ao uso de bandagens elásticas e repouso com a perna elevada

show abstract

Developmental arteriovenous malformation with secondary angiodermatitis. Report of a case

aterson¹

1969

Archives of Dermatology

View full text Add to dashboard Cite

Acro-Angiodermatitis of the Foot

Cited by 123 publications

References 1 publication

Hemosiderotic Fibrohistiocytic Lipomatous Lesion: Ten Cases of a Previously Undescribed Fatty Lesion of the Foot/ankle

Hemosiderotic Fibrohistiocytic Lipomatous Lesion: Ten Cases of a Previously Undescribed Fatty Lesion of the Foot/ankle

Acroangiodermatite (pseudossarcoma de Kaposi): uma condição raramente reconhecida. Um caso na planta do pé associado a insuficiência venosa crônica

Developmental arteriovenous malformation with secondary angiodermatitis. Report of a case

Contact Info

Product

Resources

About