1974
DOI: 10.1001/archderm.110.5.711
|View full text |Cite
|
Sign up to set email alerts
|

Acrodermatitis enteropathica. A clinical and biochemical survey

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
8
0

Year Published

1976
1976
2013
2013

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 26 publications
(8 citation statements)
references
References 40 publications
0
8
0
Order By: Relevance
“…Perhaps by increasing the efficacy of zinc uptake by functioning as an ionophore, CQ could allow for the administration of safer dosages of zinc supplementation that avoid toxic effects. Some patients fail to thrive with high-dose zinc supplementation [28] or with CQ treatment alone [31] and they might benefit most by oral CQ with zinc supplementation.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Perhaps by increasing the efficacy of zinc uptake by functioning as an ionophore, CQ could allow for the administration of safer dosages of zinc supplementation that avoid toxic effects. Some patients fail to thrive with high-dose zinc supplementation [28] or with CQ treatment alone [31] and they might benefit most by oral CQ with zinc supplementation.…”
Section: Discussionmentioning
confidence: 99%
“…In those cases CQ may have functioned to compete for available zinc and copper thereby restricting growth of the pathogens. A related compound diiodohydroxyquinoline (diodoquin) and CQ were later used to treat patients with AE but their mechanism of action was obscure at that time [27], [31]–[33] as was the etiology of AE. These compounds were withdrawn from the market in the 1970s after the appearance of SMON (sub-acute myelo-optic neuropathy) in Japan and in some AE patients [34].…”
Section: Introductionmentioning
confidence: 99%
“…In the total lipids of plasma in AEpatients, not treated or treated with diiodoquin, several authors found low linoleic acid with a normal or low arachidonic acid concentration [5,8,14,30,32,37], and in a few cases also an increased oleic acid level [5,32,37] was found. Similar patterns were also observed in patients with zinc deficiency due to parenteral nutrition, short bowel syndrome and cystic fibrosis [3,18,24,33], though insufficient supply and lipid malabsorption may have contributed to the changes in these cases.…”
Section: Discussionmentioning
confidence: 99%
“…Already, before oral zinc supplementation was introduced as an effective therapy, low levels of essential fatty acids had been reported in AE patients [8,30,32,37]. Animal experiments showed close interactions between zinc and fatty acid (FA) metabolism [4,6,9,10,20,21].…”
Section: Introductionmentioning
confidence: 99%
“…It is thought that the low proportion of this acid is not the major reason for this disease, as administration of arachidonic acid increased the amounts seen in serum without influencing the symptoms. Of many proposed theories of metabolic malfunction in acrodermatitis enteropathica (review by Nelder et al, 1974) including abnormalities of zinc metabolism, the altered metabolism of essential fatty acids is one ofthe most ill-defined. It has been proposed by Cash & Berger (1969) that there is an enzymatic defect in the conversion of co-6 eicosatrienoic acid to arachidonic acid.…”
Section: Essential Fatty Acid Deficiency and The Skin Of Manmentioning
confidence: 99%