Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas)

Lakdawala, Nikita; Grant‐Kels, Jane M.

doi:10.1016/j.clindermatol.2015.04.002

Cited by 33 publications

(25 citation statements)

References 41 publications

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“…4 A mutation in this transporter impairs zinc absorption in the duodenum and jejunum resulting in the observed deficiency. 5 The estimated worldwide prevalence of genetic AE is 1 in 500,000 children with no race or gender preference. 2 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…2,3,5,6 The prevalence of dietary zinc deficiency is estimated at 20% worldwide, and approximately 1-3% in the United States. 5 According to the American Society for Parenteral and Enteral Nutrition (ASPEN), there have been shortages of many PN products, including zinc, since 2010. 7,8 Zinc and other micronutrient deficiencies are also a major global health problem, with efforts by the United Nation Children’s Emergency Fund (UNICEF) and the World Health Organization (WHO) to provide multiple micronutrient supplements to meet the required need for vulnerable populations.…”

Section: Discussionmentioning

confidence: 99%

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Persistent Rash in a Patient Receiving Total Parenteral Nutrition

Fowler

2016

JAMA

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Persistent Rash in a Patient Receiving Total Parenteral Nutrition

Fowler

2016

JAMA

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“…oysters, crabs), meet (beef, turkey, chicken, pork), tree nuts (cashews, almonds), legumes (beans), and peanuts and whole grain. 29 Despite this, some cases partially resistant to zinc sulphate therapy have been described: in such patients high dose therapy with zinc gluconate and vitamin C has shown to improve the clinical and serological patterns. 22 As previously argued, AE may show a wide variety of clinical presentations with different scores of severity, such as clinical forms partially resistant to therapy.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity in the genetic alterations and in the clinical presentation of acrodermatitis enteropathic: Case report and review of the literature

Ricci

Ferrari

Calamelli

et al. 2015

Int J Immunopathol Pharmacol

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Acrodermatitis enteropathic (AE) is a rare autosomal recessive disorder due to a zinc deficiency and characterized by a classical triad of symptoms: dermatitis, alopecia, and diarrhea. The defective gene is SLC39A4, which encodes a zinc transporter. Nevertheless many abnormalities in SLC39A4 have been relieved, only 50% of patients show alterations. Here is reported the case of an infant with mild and incomplete manifestations of AE, for whom the SLC39A4 genetic test was performed. A novel mutation in SLC39A4 was identified. Zinc replacement improved rapidly the skin lesions. Our case highlights the importance of suspecting this rare condition and to perform the genetic test even in those patients who do not fulfil the classical triad of symptoms. Further efforts should be addressed to identify a more strength correlation between genotype and phenotype of this disorder.

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“…Cheilitis and glossitis are also commonly noted with a clinical condition similar to acrodermatitis enteropatica (AE). Dietary replacement typically requires dosages of 1-2 mg/day up to 100 mg/day, higher than the recommended daily necessity [78].…”

Section: Metabolic Deficienciesmentioning

confidence: 99%

Advances in pharmacotherapeutic management of common skin diseases in neonates and infants

Patrizi

Neri

Ricci

et al. 2017

Expert Opinion on Pharmacotherapy

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neonatal and infantile skin diseases are frequently encountered in the clinical practice and represent worldwide a socioeconomic issue. They encompass a wide range of acquired or congenital conditions, including infections, vascular lesions and inflammatory diseases and can present with different degrees of severity, leading in some cases to dramatic complications. Areas covered: In this paper we report the most recent evidences on the management of some common skin diseases in neonates and infants. Hemangiomas, viral, fungal and bacterial infections, omphalitis, atopic and seborrhoeic dermatitis, napkin disease will be treated and discussed. Expert opinion: The majority of the dermatologic alterations in neonates are physiological, transient and do not require any treatment, thus the parents can be reassured about the good prognosis. However, in some cases, serious conditions must be excluded. In particular neonatal and infantile infections should be promptly recognized and properly managed, to avoid severe complications. The therapeutic options include traditional and, although few, innovative medical treatments, which will be carefully taken into consideration by the expert Dermatologists and Paediatricians.

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Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas)

Cited by 33 publications

References 41 publications

Persistent Rash in a Patient Receiving Total Parenteral Nutrition

Persistent Rash in a Patient Receiving Total Parenteral Nutrition

Heterogeneity in the genetic alterations and in the clinical presentation of acrodermatitis enteropathic: Case report and review of the literature

Advances in pharmacotherapeutic management of common skin diseases in neonates and infants

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