Acrodermatitis Enteropathica in Two Siblings Treated with Zinc Sulphate Supplements Alone

Ej, Moynahan

doi:10.1177/003591577506800504

Cited by 4 publications

(3 citation statements)

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“…The results obtained indicate that there is only a small overall deficit of body zinc stores in this disease and that the function of di-iodohydroxyquinoline is to increase the amount of zinc absorbed and retained by the body.It has been shown that acrodermatitis enteropathica is an inherited zinc deficiency disorder (Barnes and Moynahan, 1973;Moynahan, 1975;Neldner and Hambidge, 1975)] but, the mechanism by which this …”

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confidence: 99%

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Zinc and di-iodohydroxyquinoline therapy in acrodermatitis enteropathica.

Jackson¹

1977

J Clin Pathol

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SUMMARY A 25-year-old patient with acrodermatitis enteropathica who had been treated with di-iodohydroxyquinoline for 20 years was changed to zinc sulphate therapy and studied under full metabolic balance control for zinc, calcium, magnesium, and inorganic phosphorus. The results obtained indicate that there is only a small overall deficit of body zinc stores in this disease and that the function of di-iodohydroxyquinoline is to increase the amount of zinc absorbed and retained by the body.It has been shown that acrodermatitis enteropathica is an inherited zinc deficiency disorder (Barnes and Moynahan, 1973;Moynahan, 1975;Neldner and Hambidge, 1975)] but, the mechanism by which this deficiency occurs has not been satisfactorily ascertained. Lombeck et al. (1975), in acute loading tests, showed that the defect was a reduced absorption of zinc by the gut and not an increased excretion of zinc into faeces, urine or sweat. It was postulated by Moynahan (1974) that an oligopeptide chelated the ingested zinc to yield an insoluble complex, thus reducing the zinc available for absorption. Recently, Delves et al. (1975) have suggested that di-iodohydroxyquinoline acts by complexing the zinc ions and this complex is absorbed from the gut. External zinc balances before and after change of treatment do not appear to have been described. The aim of this work was to obtain information on the mechanism of the therapeutic effect of di-iodohydroxyquinoline in this disease and to obtain a measure of the deficiency of zinc in this patient. PatientOur patient was a woman who had been diagnosed by Hare and Schlesinger (1955), at which time she had been started on di-iodohydroxyquinoline therapy, a gluten-free diet, and pancreatin. She was kept on regular follow-up, and six months later the gluten-

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mentioning

confidence: 99%

“…It has been shown that acrodermatitis enteropathica is an inherited zinc deficiency disorder (Barnes and Moynahan, 1973;Moynahan, 1975;Neldner and Hambidge, 1975)] but, the mechanism by which this…”

mentioning

confidence: 99%

Zinc and di-iodohydroxyquinoline therapy in acrodermatitis enteropathica.

Jackson¹

1977

J Clin Pathol

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“…Eine entscheidende Wende erfuhren Nosologie und Therapie der Acrodermatitis enteropathica, als sich herausstellte, daß dem Leiden ein Zinkmangel zugrunde liegt. Die Erkenntnis dieser Basisstörung verdankt die medizinische Welt in erster Linie dem Londoner Dermatologen Moynahan (10)(11)(12)(13), der anläßlich der eingehenden Untersuchung einer an Acrodermatitis enteropathica erkrankten jungen Italienerin feststellte, daß der Zinkgehalt des Plasmas erheblich erniedrigt war. Anfänglich zusätzlich zu Hydroxychinolinen, später ausschließlich verordnetes Zink (in Form von Zinksulfat) brachte nicht nur die »groben«, der Acrodermatitis enteropathica wesenseigenen Symptome zum Verschwinden, sondern auch äußeres Integument, Schleimhäute, Haar und Nägel nahmen von nun an eine dem Normalzustand weitgehend angeglichene Beschaffenheit an.…”

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Lebensrettende Zinkbehandlung der Acrodermatitis enteropathica^*

Reich¹,

Opitz²,

Bertram³

et al. 1976

Dtsch med Wochenschr

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A 24-year-old patient treated with hydroxychinoline preparations without cure for acrodermatitis enteropathica since he was nine years old was given zinc oxide orally, at first 50 mg three times, later twice daily. Zinc concentrations in blood plasma, whole blood and sputum were serially determined. At the start of treatment they were significantly below that in four healthy controls. One week after starting zinc therapy the blood level had returned to normal and with it the changes in skin, hair and nails had regressed, as had the emotional disturbances.

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