Acrolein, an environmental toxicant and its applications to in vivo and in vitro atherosclerosis models: An update

Crowley, Liana N; Le, Brandy; Cicalo, Cara; Brown, Justin; Li, Yali; Kim, Young Jun; Lee, Jin Hyup; Pan, Jeong Hoon; Lennon, Shannon L.; Han, Bok Kyung; Kim, Jae Kyeom

doi:10.1016/j.etap.2022.103890

Cited by 9 publications

(4 citation statements)

References 37 publications

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“…The Environmental Protection Agency classifies acrolein as a high-priority air and water toxicant. Strong evidence suggests that acrolein can cause damage to cardiac myocytes and endothelial cells, promoting endothelial dysfunction, vascular disease, and heart failure [92][93][94][95].…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

Pandics,

Major,

Fazekas-Pongor

et al. 2023

GeroScience

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The aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardiovascular and brain pathologies. This comprehensive review paper delves into the impact of the exposome, which encompasses the totality of environmental exposures, on unhealthy aging. It explores how environmental factors contribute to the acceleration of aging processes, increase biological age, and facilitate the development and progression of a wide range of age-associated diseases. The impact of environmental factors on cognitive health and the development of chronic age-related diseases affecting the cardiovascular system and central nervous system is discussed, with a specific focus on Alzheimer’s disease, Parkinson’s disease, stroke, small vessel disease, and vascular cognitive impairment (VCI). Aging is a major risk factor for these diseases. Their pathogenesis involves cellular and molecular mechanisms of aging such as increased oxidative stress, impaired mitochondrial function, DNA damage, and inflammation and is influenced by environmental factors. Environmental toxicants, including ambient particulate matter, pesticides, heavy metals, and organic solvents, have been identified as significant contributors to cardiovascular and brain aging disorders. These toxicants can inflict both macro- and microvascular damage and many of them can also cross the blood–brain barrier, inducing neurotoxic effects, neuroinflammation, and neuronal dysfunction. In conclusion, environmental factors play a critical role in modulating cardiovascular and brain aging. A deeper understanding of how environmental toxicants exacerbate aging processes and contribute to the pathogenesis of neurodegenerative diseases, VCI, and dementia is crucial for the development of preventive strategies and interventions to promote cardiovascular, cerebrovascular, and brain health. By mitigating exposure to harmful environmental factors and promoting healthy aging, we can strive to reduce the burden of age-related cardiovascular and brain pathologies in the aging population.

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Section: Cardiovascular Diseasesmentioning

confidence: 99%

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

Pandics,

Major,

Fazekas-Pongor

et al. 2023

GeroScience

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“…Exogenously, ACR is produced by environmental sources, such as incomplete combustion of petroleum fuels and plastics, cigarette smoke, vapors of overheated cooking oil, and even high-temperature processed food or fermented beverages. 1 Endogenously, ACR can be generated through the enzymemediated metabolism of polyamines or threonine, degradation of carbohydrates and amino acids, oxidation of unsaturated fatty acids, and microbial glycerol metabolism. 2 Recently, ACR has been classified as a "Group 2A carcinogen (probably carcinogenic to humans)" instead of the previous "Group 3 carcinogen (not classifiable as to its carcinogenicity to humans)" by the International Agency for Research on Cancer, 3 due to its ability to induce DNA strand breaks and reduce the repair capacity for DNA damage, modify cellular proteins, and alter their functions, or even cause cell death.…”

Section: ■ Introductionmentioning

confidence: 99%

“…ACR possesses the highest reactivity chemically among RCS and is a highly ubiquitous unsaturated aldehyde that humans inevitably come into contact with in many situations. Exogenously, ACR is produced by environmental sources, such as incomplete combustion of petroleum fuels and plastics, cigarette smoke, vapors of overheated cooking oil, and even high-temperature processed food or fermented beverages . Endogenously, ACR can be generated through the enzyme-mediated metabolism of polyamines or threonine, degradation of carbohydrates and amino acids, oxidation of unsaturated fatty acids, and microbial glycerol metabolism .…”

Section: Introductionmentioning

confidence: 99%

Theanine Capture of Reactive Carbonyl Species in Humans after Consuming Theanine Capsules or Green Tea

Zhong,

Yang,

et al. 2024

J. Agric. Food Chem.

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Acrolein (ACR), methylglyoxal (MGO), and glyoxal (GO) are a class of reactive carbonyl species (RCS), which play a crucial role in the pathogenesis of chronic and age-related diseases. Here, we explored a new RCS inhibitor (theanine, THE) and investigated its capture capacity on RCS in vivo by human experiments. After proving that theanine could efficiently capture ACR instead of MGO/GO by forming adducts under simulated physiological conditions, we further detected the ACR/MGO/GO adducts of theanine in the human urine samples after consumption of theanine capsules (200 and 400 mg) or green tea (4 cups, containing 200 mg of theanine) by using ultraperformance liquid chromatography–time-of-flight–high-resolution mass spectrometry. Quantitative assays revealed that THE-ACR, THE-2ACR-1, THE-MGO, and THE-GO were formed in a dose-dependent manner in the theanine capsule groups; the maximum value of the adducts of theanine was also tested. Furthermore, besides the RCS adducts of theanine, the RCS adducts of catechins could also be detected in the drinking tea group. Whereas, metabolite profile analysis showed that theanine could better capture RCS produced in the renal metabolic pathway than catechins. Our findings indicated that theanine could reduce RCS in the body in two ways: as a pure component or contained in tea leaves.

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“…Among these contaminants, propen‐2‐al (acrolein), a highly reactive α,β‐unsaturated aldehyde, is a compound that humans are exposed to in many situations and might be responsible for triggering different neurodegenerative diseases, such as cardiovascular diseases, diabetes, cancer, atherosclerosis, and Alzheimer's (Chang et al., 2022; Crowley et al., 2022; Igarashi et al., 2018; Jiang et al., 2022; Liu et al., 2019; X. Zhang et al., 2022; Zirak et al., 2019). Acrolein can be found mainly in foods and beverages that are rich in lipids, carbohydrates, and certain amino acids that are heated during processing, or in fermented products produced by the metabolism of lactic acid bacteria (Drakula et al., 2019; Lago & Welke, 2019; Muguruma et al., 2020; D. Zhang et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Correlation of the presence of acrolein with higher alcohols, glycerol, and acidity in cachaças

Alvarenga

Machado

Barbosa

et al. 2023

Journal of Food Science

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Acrolein is a toxic aldehyde that can be present in various beverages, such as cachaça and other distilled spirits from sugarcane. The objective of this work was to detect and quantify acrolein in samples of cachaça produced by different processes in all regions of Brazil and to evaluate the possible routes of formation of this contaminant from the correlation with other secondary compounds present in the beverage using principal component analysis. Approximately 27.0% of the samples analyzed were outside the limit established by Brazilian legislation for this contaminant, with an average acrolein concentration of 14.01 mg 100 mL −1 anhydrous alcohol (aa). In the other samples, the average concentration was 0.97 mg 100 mL −1 aa. After selecting the variables that most closely correlated with the presence of acrolein in beverages, a positive correlation was found with the presence of butan-2-ol, propan-1-ol and volatile acids, and a slight correlation with the presence of phenolic compounds. Therefore, the presence of acrolein in cachaça can be associated with contamination of the fermentation must by bacteria of the genus Lactobacillus, as a result of the chemical degradation and enzymatic conversion of the glycerol produced during fermentation.

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Acrolein, an environmental toxicant and its applications to in vivo and in vitro atherosclerosis models: An update

Cited by 9 publications

References 37 publications

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

Theanine Capture of Reactive Carbonyl Species in Humans after Consuming Theanine Capsules or Green Tea

Correlation of the presence of acrolein with higher alcohols, glycerol, and acidity in cachaças

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