Acromegaly: A Cross-Sectional Analysis of the Oral and Maxillofacial Pathologies

Herrmann, Benedikt; Mortsch, Florentine; Berg, C; Weischer, Thomas; Mohr, Christopher; Mann, Keith O.

doi:10.1055/s-0030-1255020

Cited by 30 publications

(33 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is consistent with a clinical report showing increased lateral growth in the mandibles of humans with acromegaly, which is expected to induce the lateral cross-bite in these patients [25]. Indeed, a previous study using plaster models of 28 case of acromegaly demonstrated that the mandible was larger than the maxilla in 32% of patients, and that the maxilla was captured in the mandible in one patient [5]. An enlarged tongue should be one of the explanation of the remarkable lateral dental arch expansion in the mandible because tongue enlargement would have the potential to widen the arch by applying lateral pressure to the teeth.…”

Section: Effects Of Igf-i Administrationsupporting

confidence: 91%

Morphological and Histopathological Changes in Orofacial Structures of Experimentally Developed Acromegaly-Like Rats: An Overview

Iikubo

Kojima

Sakamoto

et al. 2012

International Journal of Endocrinology

View full text Add to dashboard Cite

Tongue enlargement and mandibular prognathism are clinically recognized in almost all patients with acromegaly. An acromegaly-like rat model recently developed by exogenous administration of insulin-like growth factor I (IGF-I) was used to investigate morphological and histopathological changes in orofacial structures and to clarify whether these changes were reversible. Exogenous administration of IGF-I evoked specific enlargement of the tongue with identifiable histopathological changes (increased muscle bundle width, increased space between muscle bundles, and increased epithelial thickness), elongation of the mandibular alveolar bone and ascending ramus, and lateral expansion of the mandibular dental arch. Regarding histopathological changes in the mandibular condyle, the cartilaginous layer width, bone matrix ratio, and number of osteoblasts were all significantly greater in this rat model. After normalization of the circulating IGF-I level, tongue enlargement and histopathological changes in the tongue and mandibular condyle were reversible, whereas morphological skeletal changes in the mandible remained.

show abstract

Section: Effects Of Igf-i Administrationsupporting

confidence: 91%

Morphological and Histopathological Changes in Orofacial Structures of Experimentally Developed Acromegaly-Like Rats: An Overview

Iikubo

Kojima

Sakamoto

et al. 2012

International Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…This observation is similar to other systemic complications in acromegaly, such as cardiomyopathy, arrhythmias and cranio-facial alterations [1,19,20]. The untreated GH and IGF-I excess induces prognathism, increases tongue volume and enlarges uvula which narrow the upper airway and hence generate signs and symptoms of OSA [5,21,22].…”

Section: Discussionsupporting

confidence: 76%

Obstructive Sleep Apnea Syndrome Is Less Frequent in Patients With Well-Controlled Acromegaly Treated With Somatostatin Analogues, Pegvisomant or in Combination

Herrmann¹,

Stalla

Laubner

et al. 2017

J Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…In contrast, lower facial depth reflects the length of the mandible. This finding is likely dependent on the growth hormone status of an individual and it is widely known that conditions of GH hypersecretion, such as acromegaly, are linked to mandibular prognathism [Herrmann et al, 2011].…”

Section: Discussionmentioning

confidence: 98%

Characterization of facial phenotypes of children with congenital hypopituitarism and their parents: A matched case‐control study

Manousaki

Allanson

Wolf

et al. 2015

American J of Med Genetics Pt A

View full text Add to dashboard Cite

Congenital Hypopituitarism (CH) has traditionally been associated with specific facial phenotypes subsumed under the term midface retrusion, based on cephalometric studies. In this study, we used a systematic anthropometric approach to facial morphology in 37 individuals with CH and their parents, primarily of French Canadian ancestry, and compared them to a control group of 78 French Canadian patients with well-controlled type 1 diabetes and their parents. We were able to demonstrate clear morphological differences, which were more prevalent in the affected group than in the control group. More specifically, we showed the presence of a shorter skull base width (P < 0.001) and reduced inner canthal distance (P = 0.006) in the CH face, as well as a relative underdevelopment of the mandible (P = 0.001). These findings were present in individuals of all ages, and were independent of the duration of growth hormone treatment (median treatment 90.8 months; range 7.2-175.8 months). In addition, skull base width was significantly reduced in both mothers and fathers of affected children compared to the parents of the controls (P < 0.001), despite comparable parental heights, supporting an underlying genetic etiology. Such extensive phenotypic studies have not been done in congenital hypopituitarism and will provide further opportunities for data mining.

show abstract

Acromegaly: A Cross-Sectional Analysis of the Oral and Maxillofacial Pathologies

Cited by 30 publications

References 16 publications

Morphological and Histopathological Changes in Orofacial Structures of Experimentally Developed Acromegaly-Like Rats: An Overview

Morphological and Histopathological Changes in Orofacial Structures of Experimentally Developed Acromegaly-Like Rats: An Overview

Obstructive Sleep Apnea Syndrome Is Less Frequent in Patients With Well-Controlled Acromegaly Treated With Somatostatin Analogues, Pegvisomant or in Combination

Characterization of facial phenotypes of children with congenital hypopituitarism and their parents: A matched case‐control study

Contact Info

Product

Resources

About