Acromegaly and aging: A comparative cross-sectional study

Hatipoğlu, Esra; Yürüyen, Mehmet; Keskin, Ela; Yavuzer, Hakan; Niyazoğlu, Mutlu; Döventaş, Alper; Erdinçler, Deniz Suna; Beger, T.; Kadıoğlu, Pınar; Gündoğdu, Sadi

doi:10.1016/j.ghir.2014.12.003

Cited by 19 publications

(17 citation statements)

References 34 publications

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“…1B). One previous cross-sectional casecontrolled study could not find a difference in hand grip strength among 30 elderly patients with acromegaly (16 with uncontrolled disease) compared to controls (36). The discrepancy to our study may be due to the heterogeneous population in this previous study with patients with and without biochemical remission as well as using elderly patients.…”

Section: Discussioncontrasting

confidence: 94%

Muscle strength in patients with acromegaly at diagnosis and during long-term follow-up

Füchtbauer

Olsson

Bengtsson

et al. 2017

European Journal of Endocrinology

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Section: Discussioncontrasting

confidence: 94%

Muscle strength in patients with acromegaly at diagnosis and during long-term follow-up

Füchtbauer

Olsson

Bengtsson

et al. 2017

European Journal of Endocrinology

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“…The disease-specific factor hypopituitarism was described to have no significant effect (39, 41, 56, 65), while previous/ongoing treatments could not be associated with QoL in acromegaly [i.e., any treatment of acromegaly (not otherwise specified) (10, 21), surgery vs. somatostatin analogs (57, 65)] and physical activity (33). Other predictors were either not reported, or no consensus was reached on other predictors, such as the demographic factors age and gender, the biochemical parameters GH, IGF1, or biochemical control, and the duration of either disease or remission.…”

Section: Resultsmentioning

confidence: 99%

Predictors of Quality of Life in Acromegaly: No Consensus on Biochemical Parameters

et al. 2017

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BackgroundQuality of life (QoL) in patients with acromegaly is reduced irrespective of disease state. The contributions of multifactorial determinants of QoL in several disease stages are presently not well known.ObjectiveTo systematically review predictors of QoL in acromegalic patients.MethodsMain databases were systematically searched using predefined search terms for potentially relevant articles up to January 2017. Inclusion criteria included separate acromegaly cohort, non-hereditary acromegaly, QoL as study parameter with clearly described method of measurement and quantitative results, N ≥ 10 patients, article in English and adult patients only. Data extraction was performed by two independent reviewers; studies were included using the PRISMA flow diagram.ResultsWe identified 1,162 studies; 51 studies met the inclusion criteria: 31 cross-sectional observational studies [mean AcroQoL score 62.7 (range 46.6–87.0, n = 1,597)], 9 had a longitudinal component [mean baseline AcroQoL score 61.4 (range 54.3–69.0, n = 386)], and 15 were intervention studies [mean baseline AcroQoL score 58.6 (range 52.2–75.3, n = 521)]. Disease-activity reflected by biochemical control measures yielded mixed, and therefore inconclusive results with respect to their effect on QoL. Addition of pegvisomant to somatostatin analogs and start of lanreotide autogel resulted in improvement in QoL. Data from intervention studies on other treatment modalities were too limited to draw conclusions on the effects of these modalities on QoL. Interestingly, higher BMI and greater degree of depression showed consistently negative associations with QoL. Hypopituitarism was not significantly correlated with QoL in acromegaly.ConclusionAt present, there is insufficient published data to support that biochemical control, or treatment of acromegaly in general, is associated with improved QoL. Studies with somatostatin receptor ligand treatment, i.e., particularly lanreotide autogel and pegvisomant have shown improved QoL, but consensus on the correlation with biochemical control is missing. Longitudinal studies investigating predictors in treatment-naive patients and their follow-up after therapeutic interventions are lacking but are urgently needed. Other factors, i.e., depression and obesity were identified from cross-sectional cohort studies as consistent factors associated with poor QoL. Perhaps treatment strategies of acromegaly patients should not only focus on normalizing biochemical markers but emphasize improvement of QoL by alternative interventions such as psychosocial or weight lowering interventions.

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“…Compliance of the controlled acromegaly patients to complex activities including colonoscopy preparation seems to be better than uncontrolled active acromegaly group. Impaired daily complex activities are reproted in acromegalic patients (20). In the whole cohort, CIT had tendency towards prolongation in cases with inadequate bowel cleansing.…”

Section: Discussionmentioning

confidence: 86%

Longer Cecum Insertion Time and More Inadequate Colonic Preparation in Patients with Acromegaly: is a Different Colonoscopy Preparation Needed?

et al. 2017

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purpose. To investigate whether there is a difference between acromegalic and non-acromegalic cases in terms of bowel preparation and colonoscopic intervention. methods. Patients with controlled and uncontrolled acromegaly and as a control group (CG) patients without acromegaly between January 2010 and March 2014 were included. Groups were compared regarding adequacy of bowel preparation, cecal insertion time (CIT) and colonoscopy results. results. Fifty-nine patients with acromegaly (controlled n=30, uncontrolled n=29) and 73 age and gender matched volunteers without acromegaly were evaluated. CIT in cases with controlled, uncontrolled acromegaly cases and in CG was 5.33 [4.00-6.00], 7.00 [4.91-11.31], and 3.10 [2.35-4.65] minutes, respectively (p<0.001). Cases in CG had shorter CIT compared to controlled and uncontrolled acromegaly cases (p=0.014 and p<0.001, respectively). There was no significant difference regarding CIT between controlled and uncontrolled acromegaly cases (p=0.247). Six (20%) of controlled acromegaly patients, 10 (35%) of uncontrolled acromegaly patients and three (4%) of CG had inadequate bowel cleansing (p<0.001). Although statistically insignificant, cases with inadequate bowel cleansing had tendency towards having prolonged CIT in comparison to cases with adequate bowel cleansing (6.00 [3.87-9.00] and 4.16 [2.95-5.70] minutes, respectively, p=0.07). conclusion. Inadequate bowel cleansing is one of the main problems encountered during colonoscopic investigation/surveillance in acromegalic patients. Therefore, a different protocol for colonoscopy preparation may be needed for these cases.

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Acromegaly and aging: A comparative cross-sectional study

Cited by 19 publications

References 34 publications

Muscle strength in patients with acromegaly at diagnosis and during long-term follow-up

Muscle strength in patients with acromegaly at diagnosis and during long-term follow-up

Predictors of Quality of Life in Acromegaly: No Consensus on Biochemical Parameters

Longer Cecum Insertion Time and More Inadequate Colonic Preparation in Patients with Acromegaly: is a Different Colonoscopy Preparation Needed?

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