Acromegaly and Hyperthyroidism Associated with McCune-Albright Syndrome

Abstract

A 36-year-old man is described having McCune-Albright syndrome, acromegaly likely due to somatotroph hyperplasia and hyperthyroidism due to adenomatous goiter. Sexual precocity was not noted. The sella was narrow in size and no mass was seen. The decline of elevated GH by hyperglycemia and increase by GHRH-44(NH₂) may support somatotroph hyperplasia, but plasma GHRH-44(NH₂) levels were not elevated. A mass in the right lobe and enlargement of the left lobe of the thyroid were noted. Thyroid hormone levels in serum and thyroidal radioiodine uptake values were elevated, while TSH measurements in serum were low. The radioiodine scan showed a cold nodule in the right lobe and a hot area in the left of the thyroid. Thyroidal radioiodine was not suppressed following T₃ given orally. These findings are compatible with functioning glands autonomously as the mechanism for the endocrinopathies associated with the McCune-Albright syndrome.

Polyostotic fibrous dysplasia with gigantism and huge pelvic tumor: a rare case of McCune–Albright syndrome

“…PFD occurs in various syndromes [1][2][3][4][5][6][7][8][9][10][11][12][13][14]; hence, diagnosis was difficult in the present case. Although no mental retardation was evident, gigantism was a prominent feature; this was attributable to pituitary adenoma and was associated with genital hypoplasia, hematologically advanced anemia, and elevated bone resorption markers.…”

“…However, the conditions leading to polyostotic fibrous dysplasia (PFD) are comparatively rare [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Although PFD has been reported in various syndromes, only a few reports of the condition occurring as a complication of gigantism have been published [1-6, 15, 16].…”

Thyroid sonographic abnormalities in McCune-Albright syndrome

“…Additional endocrinological disorders have been described as part of this syndrome including hyperthyroidism, acromegaly, hyperparathyroidism and Cushing's syndrome [1,2]. The most commonly reported of these involve the thyroid gland [3].…”