Acrometastasis showing an occult lung cancer

Gilardi, Roberta; Rosa, Norman Della; Pancaldi, G; Landi, Antonio

doi:10.3109/2000656x.2012.748319

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…Repeated trauma might reduce local tissue resistance explaining why the dominant hand is more frequently affected. Thermal imbalances, hemodynamic factors, lack of red marrow in adult small bones, and chemotactic factors have also been suggested [7,8,9]. These factors, including prostaglandins, promote cell migration and adhesion to bon, and may create a conduit for metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

What is the prognostic significance of acrometastases?

Baltazard¹,

Arnault²,

Dillied³

et al. 2015

Dermatology Online Journal

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In contrast with bone metastasis, acrometastases are uncommon and are associated with advanced cancer. We report the cases of two patients with atypical lesions of the fingers in a context of cancer, in which biopsies confirmed a metastasis. Patients died rapidly before treatment was initiated. We discuss the characteristics of these atypical metastatic sites, associated with a generally poor prognosis.

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Section: Discussionmentioning

confidence: 99%

What is the prognostic significance of acrometastases?

Baltazard¹,

Arnault²,

Dillied³

et al. 2015

Dermatology Online Journal

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“…Good primary tumor and metastatic tumor control are due to targeted therapy [ 9 ]. The local intralesional excision, alcohol ablation, and impaction artificial bone grafting are salvage procedures for preventing further cortical collapse and deformation of the metacarpal.…”

Section: Discussionmentioning

confidence: 99%

Acrometastasis to metacarpal bone disclosing an occult lung cancer

Liu

et al. 2014

Case Reports in Plastic Surgery and Hand Surgery

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“…Occult lung cancer, defined as the presence of malignant tumor cells in bronchial washing or sputum but demonstrated no tumor evidence by imaging [ 1 , 2 ], often manifests as metastasis diseases [ 3 , 4 , 5 ] or other internal diseases such as stroke [ 6 , 7 , 8 , 9 ], venous thromboembolism [ 10 , 11 ] and dermatomyositis [ 12 ]. When these patients develop apparent non-cancer-related symptoms, the vast majority may have already progressed to an advanced stage.…”

Section: Introductionmentioning

confidence: 99%

“…Owing to the ambiguous TNM stage, the prognosis of this subgroup disease is still an enigma, and elucidation of prognostic indicators is therefore necessary to define high-risk patients who may derive benefit from more intensive care. Following extensive literature review, due to the low incidence (about 0.53%) [ 8 ] and lack of tumor evidence by imaging [ 1 , 2 ], the number of related researches is still modest, and most of them are case reports [ 3 , 4 , 5 , 7 , 8 , 9 , 11 ]. The lack of clinical data makes the natural course of occult NSCLC far from understood and the establishment of corresponding therapeutic strategies impossible, and it also compromises efforts to define prognostic factors for occult NSCLC.…”

Section: Introductionmentioning

confidence: 99%

Occult Non-Small Cell Lung Cancer: An Underappreciated Disease

Cai

Yang

Wang

2022

JCM

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Background: The number of researches on occult non-small cell lung cancer (NSCLC) is modest. Herein, we defined the clinicopathological features, prognosis and survival outcome of this underappreciated tumor, with purpose of obtaining a clearer picture on this disease. Methods: The entire cohort was categorized into two groups (occult NSCLC and other NSCLC) and further into five groups (occult, T1, T2, T3 and T4). A least absolute shrinkage and selection operator (LASSO) penalized Cox regression model was performed to identify the prognostic indicators. A nomogram and a risk-classifying system were formulated. Kaplan–Meier with Log-rank method was carried out to compare overall survival (OS) and cancer specific survival (CSS) differences between groups. Results: 59,046 eligible NSCLC cases (occult NSCLC: 1158 cases; other NSCLC: 57,888 cases) were included. Occult NSCLC accounted for 2.0% of the included cases. Multivariate analysis revealed that age, sex, tumor location, histology, grade and surgery were prognostic factors for OS. The corresponding prognostic nomogram classified occult NSCLC patients into low-risk and high-risk group, and its performance was acceptable. Survival curves demonstrated that occult NSCLC patients exhibited worse survivals than other NSCLC. In further analyses, the survival of low-risk occult NSCLC and stage T3 NSCLC were comparable, and the high-risk occult NSCLC patients still owned the worst survival rate. Conclusions: Occult NSCLC was an aggressive tumor with poor prognosis, and surgery was the preferred treatment. More attention should be paid to this overlooked disease due to no evidence of tumor imaging.

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Acrometastasis showing an occult lung cancer

Abstract: The purpose of this paper was to present a case of an occult lung cancer diagnosed by the presenceof a carpal bone metastatic lesion.

Cited by 7 publications

References 9 publications

What is the prognostic significance of acrometastases?

What is the prognostic significance of acrometastases?

Acrometastasis to metacarpal bone disclosing an occult lung cancer

Occult Non-Small Cell Lung Cancer: An Underappreciated Disease

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