Acrosome Reaction and Lysins

Dan, Jean Clark

doi:10.1016/b978-1-4832-2776-4.50012-5

Cited by 104 publications

(54 citation statements)

References 70 publications

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“…The acrosome reaction of sperm is an essential event for fertilization in most animals (Dan, 1967). It involves the exocytosis of the acrosomal vesicle to expose the devices for penetration through the egg coats and for subsequent fusion with the egg plasma membrane (Longo, 1997).…”

Section: Introductionmentioning

confidence: 99%

Characterization of the Sperm Receptor for Acrosome Reaction-Inducing Substance of the Starfish, Asterias Amurensis

2002

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Section: Introductionmentioning

confidence: 99%

Characterization of the Sperm Receptor for Acrosome Reaction-Inducing Substance of the Starfish, Asterias Amurensis

2002

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“…From this point of view and assuming that the acrosome reaction is an irreversible process, no "capacitating effect" is to be expected after the treatment of the already "reacted spermatozoa" of a diluted sperm suspension with such a protective factor. Taking into account that hydrolytic enzymes are generally given off in solution as a result of the acrosome reaction (DAN, 1967), and that this reaction does also occur in the amphibian spermatozoon (RAISMAN, 1970), the following observation deserves to be recalled in this connection. It has been found that a spermatolysin which attacks the vitelline membrane of B. arenarum oocytes (RAISMAN and BARBIERI, 1969) is not released from the spermatozoa as far as they are kept in dense suspensions; upon dilution, however, the enzyme is immediately given off in solution (unpublished observations).…”

Section: Discussionmentioning

confidence: 99%

A Study of the Diffusible Factor Released by the Jelly of the Egg of the Toad, Bufo Arenarum

Barbieri

Oterino

1972

Dev Growth Differ

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Some properties of an essential factor for fertilization released from the oocyte strings of the toad, Bufo arenarum were studied. All the experiments were carried out with a partially purified preparation of this diffusible factor, and the general procedure consisted in assaying under different conditions its capacity to recover the fertilizability of oocytes previously deprived of this active substance. Using this procedure, a test was devised for estimating the diffusible factor activity. As regards the mechanism of action of this fertilization factor the data reported here are not consistent with the previous assumption that the factor plays its role in fertilization through a simple pH rise of the inseminating medium. Treatment of the gametes with the diffusible factor before insemination proved to be ineffective to promote fertilization; the factor must be present at the very moment of insemination.

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“…The development of a distinctive 'frenzied' whip-lash motility seemed to mark the completion of capacitation. Blood serum (heated to destroy complement) was later shown to contain two factors with the same properties as those in follicular fluid (Yana¬ gimachi, 1970a;Barros & Garavagno, 1970 Dan, 1967) and a few years later the mam¬ malian acrosome reaction was recognized (Austin & Bishop, 1958). Its occur¬ rence, as seen by phase-contrast microscopy, was recorded in the golden and Chinese hamsters, the Libyan jird and the guinea-pig.…”

Section: Capacitationmentioning

confidence: 98%