Acrosyringeal Adenomatosis (Eccrine Syringofibroadenoma of Mascaro)

Hara, Kazuo; Mizuno, Eiji; Nitta, Yukiko; Ikeya, Toshihiko

doi:10.1097/00000372-199208000-00008

Cited by 35 publications

(12 citation statements)

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“…The second group, of which only eight patients have been described, presents with numerous widespread papular or nodular lesions. 9,15,19,20,25,31 Three of the affected individuals suffered from other systemic diseases such as non-insulin-dependent diabetes mellitus, sinusitis and otitis media. 9,19,20 The differential diagnosis in these patients includes multiple eccrine poromata, a disseminated infectious disease such as a deep fungal infection, or in cases that are regionally distributed, a systematized epidermal naevus.…”

Section: Discussionmentioning

confidence: 99%

Eccrine syringofibroadenomatosis associated with hidrotic ectodermal dysplasia

Simpson

Styles

Cockerell

1998

British Journal of Dermatology

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Eccrine syringofibroadenoma (ES) is generally regarded as a solitary benign adnexal neoplasm of the skin. Recently, the epithelial and stromal changes of this lesion have been recognized as being a reaction pattern in certain settings. We describe two individuals in whom this process was a manifestation of hidrotic ectodermal dysplasia. In both cases, the diagnosis had been missed for many years and the process had been thought to be a manifestation of an inflammatory dermatosis of the palms and soles. In both instances, other family members were found to be affected. Thus, ES may be manifested clinically as erythematous erosive plaques, especially of the palms and soles. It is important that clinicians be familiar with this disorder and be aware that it may exhibit unusual cutaneous manifestations.

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Section: Discussionmentioning

confidence: 99%

Eccrine syringofibroadenomatosis associated with hidrotic ectodermal dysplasia

Simpson

Styles

Cockerell

1998

British Journal of Dermatology

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“…Eccrine syringofibroadenoma (ESFA) is a histological entity with widely varying clinical presentations. ESFA was first described by Mascaro in 1963, 1 and most of the reported patients were in their seventh and eighth decades of life.…”

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confidence: 99%

Characterizing the nature of eccrine syringofibroadenoma: illustration with a case showing spontaneous involution

Tey

2009

Clinical and Experimental Dermatology

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Eccrine syringofibroadenoma (ESFA) is a histological entity. It has been widely debated as to whether ESFA is a true neoplasm, a hamartoma or a form of reactive hyperplasia. ESFA should not be considered a homogenous condition and there are five clinical subtypes: (i) multiple ESFA associated with ectodermal dysplasia, (ii) multiple ESFA without cutaneous features (both hamartomatous), (iii) unilateral linear ESFA (naevoid), (iv) solitary ESFA (neoplastic) and (v) reactive ESFA, which seems to start off as pathologically hyperplastic and then become hamartomatous. We report a patient with reactive ESFA secondary to lepromatous leprosy, showing spontaneous involution in an area of her lesions. Reactive ESFA represents a hyperplastic and hamartomatous process, and may be more appropriately known as reactive eccrine syringofibroadenomatosis. The risk of malignancy is low in reactive ESFA, and monitoring instead of excision is a reasonable option.

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“…Sweat gland proliferation has been previously reported in a variety of inflammatory skin diseases, as well as benign and malignant neoplasms [19]. Hara et al [20] also reported syringoma-like structures intimately associated with epithelial cords in ESFA. Thus, syringoid ductal blocked by treatment with 0.3 % H 2 O 2 in methanol for 15 min.…”

Section: Discussionmentioning

confidence: 92%