Acrylamide: A Neurotoxin and a Hazardous Waste

Cota, Prathyusha; Saha, Sayantani; Tewari, Shailvi; Sasikumar, Abhirami; Saran, M. Yashwant; Senthilkumar, Swetha; Mohideen, Sahabudeen Sheik

doi:10.5772/intechopen.102607

Cited by 2 publications

(2 citation statements)

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“…Acrylamide is a common chemical found in molecular biology labs as well as a wide range of manufacturing and processing operations. For example, food cooked at high temperatures forms acrylamide thereby humans are exposed to acrylamide with widely used TiO 2 NPs in a variety of ways through their nutrition, work, leisure activities, and other daily routines and surroundings 27 , 28 . However, the impact of acrylamide coadministration with TiO 2 NPs on genomic integrity and apoptosis induction in brain tissue has not been well studied.…”

Section: Discussionmentioning

confidence: 99%

Estimation of genotoxicity, apoptosis and oxidative stress induction by TiO2 nanoparticles and acrylamide subacute oral coadministration in mice

Safwat

Mohamed

2022

Sci Rep

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Acrylamide is used in the industry and can be a by-product of high-temperature food processing which has toxic potential in various tissues, and titanium dioxide nanoparticles (TiO2NPs) are widely used in toothpaste, sweets, food perseveration, chewing gum and medicines. Consequently, humans are daily exposed to large amounts of acrylamide and TiO2NPs mainly through food intake. However, limited studies are available on the effect of simultaneously intake of acrylamide and TiO2NPs on the integrity of genomic DNA and the induction of apoptosis in brain tissues. Therefore, this study estimated the influence of acrylamide coadministration on TiO2NPs induced genomic instability and oxidative stress in the brain tissues of mice. To achieve this, mice were orally administrated acrylamide (3 mg/kg b.w) or/and TiO2NPs (5 mg/kg b.w) for two successive weeks (5 days per week). The comet assay results showed that concurrent oral administration of acrylamide and TiO2NPs strongly induced single- and double stranded DNA breaks, and that the level of reactive oxygen species (ROS) was also highly elevated within neural cells after simultaneous oral intake of acrylamide and TiO2NPs compared to those observed after administration of acrylamide or/TiO2NPs alone. Moreover, oral co-administration of acrylamide with TiO2NPs increased apoptotic DNA damage to neurons by upregulating the expression levels of P53, TNF-α, IL-6 and Presenillin-1 genes compared to groups administered TiO2NPs. Therefore, from these results, the present study concluded that coadministration of acrylamide renders TiO2NPs more genotoxic and motivates apoptotic DNA damage and oxidative stress induced by TiO2NPs in brain cells, and thus it is recommended to avoid concurrent oral acrylamide administration with TiO2NPs.

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Section: Discussionmentioning

confidence: 99%

Estimation of genotoxicity, apoptosis and oxidative stress induction by TiO2 nanoparticles and acrylamide subacute oral coadministration in mice

Safwat

Mohamed

2022

Sci Rep

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“…In recent times, there is a wide application of aluminum salt and synthetic organic polymer such as polyacryl amide derivatives and polyethylene amine for water treatment [ 10 , 11 ]. These organic polymers contain residual monomers which are highly undesirable because of their neurotoxicity [ [12] , [13] , [14] ]. Ceramic membranes are favorable over these polymeric membranes because they have longer life with less replacement and lower operational cost [ 15 ].…”

Section: Introductionmentioning

confidence: 99%