Acrylamide-derived DNA adducts in human peripheral blood mononuclear cell DNA: Correlation with body mass

Hemgesberg, Maximilian; Stegmüller, Simone; Cartus, Alexander; Hemmer, Selina; Püttmann, Michael; Stockis, Jean-Pierre; Schrenk, Dieter

doi:10.1016/j.fct.2021.112575

Cited by 13 publications

(7 citation statements)

References 53 publications

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“…Finally, Kim et al [ 48 ] reported that a fermented black rice bran formulation inhibited ethyl alcohol-induced hangovers in mice and rats. As the molecular mechanism of the in vivo hangover effect induced by alcohol-derived acetaldehyde (CH 3 -CH=O) described in Kim et al [ 48 ] is similar to that of bioalkylation of essential proteins [ 49 ] and DNA [ 50 ] by acrylamide [(CH 2 =CH-C=O(NH 2 )], it is likely that the new functional anti-hangover food formulation can also inhibit the adverse in vivo effects of acrylamide.…”

Section: Resultsmentioning

confidence: 99%

Low Acrylamide Flatbreads Prepared from Colored Rice Flours and Relationship to Asparagine and Proximate Content of Flours and Flatbreads

Kahlon

Wang

et al. 2021

Foods

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Acrylamide is a potentially toxic compound present in many plant-based foods, such as coffee, breads, and potato fries, which is reported to have carcinogenic, neurotoxic, and antifertility properties in vivo, suggesting the need to keep the acrylamide content of widely consumed food as low as possible. As pigmented rice contains bioactive phenolic and flavonoid compounds, the objective of this study was to potentially enhance the beneficial properties of flatbreads by evaluating the acrylamide content and proximate composition of 12 novel flatbreads prepared from the following commercial pigmented rice seeds: Black Japonica, Chinese Black, French Camargue, Himalayan Red, Long Grain Brown, Purple Sticky, Short Grain Brown, Wehani, Wild, Indian Brown Basmati, Organic Brown Jasmine, and Organic Jade Pearl. Although acrylamide levels ranged from 4.9 µg/kg in Long Grain Brown to 50.8 µg/kg in Chinese Black, the absolute values were all low (though statistically significantly differences existed among varieties). Acrylamide content did not correlate with its precursor asparagine. The variations in protein, carbohydrate, fat, ash, dry matter, and water content determined by proximate analysis, and the reported health benefits of colored rice cultivars used to prepare the flatbreads, might also be useful for relating composition to nutritional qualities and health properties, facilitating their use as nutritional and health-promoting functional foods.

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Section: Resultsmentioning

confidence: 99%

Low Acrylamide Flatbreads Prepared from Colored Rice Flours and Relationship to Asparagine and Proximate Content of Flours and Flatbreads

Kahlon

Wang

et al. 2021

Foods

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“…According to Hemgesberg et al. (2021), certain proteins have sulfhydryl groups, which show high reactivity with AA. The post‐translational processing of immature TSH involves glycosylation, folding, and binding between of α and β subunits and modifications in the addition of sugars; all these steps are very crucial for TSH molecules for maturation and its ability to bind with TSH receptors.…”

Section: Harmful Effects On Bodymentioning

confidence: 99%

Possible metabolic effect of acrylamide on biological system

Gupta,

Singh,

Soni

et al. 2023

Food Safety and Health

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Acrylamide (AA) is a chemical agent mostly used in the manufacture of polymers and copolymers. Recently, it has gained attention because of its production in food items prepared at high‐temperature (>120°C) processes, such as frying, toasting, cooking, roasting or baking of high carbohydrate food items. As per the higher exposure of AA, appropriate identification of its toxic effect is necessary. Hepatotoxicity, nephrotoxicity, neurotoxicity, reproductive toxicity, and immunotoxicity of AA have been observed in several studies. AA could also be considered as endocrine‐disrupting chemicals and its exposure leads to many hormonal abnormalities. Nearly one in every four couples of a developing nation suffers from infertility, and AA exposure may be one of the reasons. AA is proven as a potent reproductive toxicant, affecting both male and female reproductive organ functioning. This review summarizes research conducted on the toxicity of AA in various organs.

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“…Low levels of N7‐GA‐Gua were identified in peripheral blood mononuclear cells (PBMCs) of 56 healthy human volunteers with N7‐GA‐Gua being detected in 80% of participants (Hemgesberg et al, 2021b ). The mean levels ranged from the LOD value (0.2 adducts per 10 8 nucleosides) to 26.6 adducts per 10 8 nucleosides.…”

Section: Assessmentmentioning

confidence: 99%

“…Oxidative stress has been discussed as an endogenous source of acrolein (Uchida, 1999 ). The association between GA‐N7‐Gua in peripheral blood mononuclear cells from human volunteers with the BMI was suggested to be due to lipid peroxidation and acrolein formation (Hemgesberg et al, 2021b ).…”

Section: Assessmentmentioning

confidence: 99%

Assessment of the genotoxicity of acrylamide

Benford¹,

Bignami²,

Chipman³

et al. 2022

EFS2

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EFSA was requested to deliver a statement on a recent publication revisiting the evidence for genotoxicity of acrylamide (AA). The statement was prepared by a Working Group and was endorsed by the CONTAM Panel before its final approval. In interpreting the Terms of Reference, the statement considered the modes of action underlying the carcinogenicity of AA including genotoxic and non‐genotoxic effects. Relevant publications since the 2015 CONTAM Panel Opinion on AA in food were reviewed. Several new studies reported positive results on the clastogenic and mutagenic properties of AA and its active metabolite glycidamide (GA). DNA adducts of GA were induced by AA exposure in experimental animals and have also been observed in humans. In addition to the genotoxicity of AA, there is evidence for both secondary DNA oxidation via generation of reactive oxygen species and for non‐genotoxic effects which may contribute to carcinogenesis by AA. These studies extend the information assessed by the CONTAM Panel in its 2015 Opinion, and support its conclusions. That Opinion applied the margin of exposure (MOE) approach, as recommended in the EFSA Guidance for substances that are both genotoxic and carcinogenic, for risk characterisation of the neoplastic effects of AA. Based on the new data evaluated, the MOE approach is still considered appropriate, and an update of the 2015 Opinion is not required at the present time.

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Acrylamide-derived DNA adducts in human peripheral blood mononuclear cell DNA: Correlation with body mass

Cited by 13 publications

References 53 publications

Low Acrylamide Flatbreads Prepared from Colored Rice Flours and Relationship to Asparagine and Proximate Content of Flours and Flatbreads

Low Acrylamide Flatbreads Prepared from Colored Rice Flours and Relationship to Asparagine and Proximate Content of Flours and Flatbreads

Possible metabolic effect of acrylamide on biological system

Assessment of the genotoxicity of acrylamide

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