Acrylonitrile: In vivo cytogenetic studies in mice and rats

Rabello-Gay, Maria Nazareth; Ahmed, Ahmed E.

doi:10.1016/0165-1218(80)90072-5

Cited by 33 publications

(9 citation statements)

References 7 publications

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“…Addition of S9 mix from Aroc1or 1254 pretreated rat liver had no detectable effect on the mutagenic activity of ACN (Venitt et al, 1977 . (1977) 8 Rabello, Gay, and Ahmed (1980) Aberration meta phases 8 in rat bone marrow cells Chromosome aberration in mice bone marrow cells Micronuclei Chromosome aberration in human lymphocyte 8 G 8 Leonard el al. (1981) Thiess and Fleig (1978) a A: + fortified liver fraction: B: = fortified liver fraction: C: gas phase: 0: liquid medium: E: urines.…”

Section: Mutagenicitymentioning

confidence: 97%

“…Pretreatment of the animals with pyrazole, an inhibitor of alcohol dehydrogenase, reduced the mutagenic activity ofthe urine which was then completely suppressed after pretreatment of the animals with COCh or SKF 525-A, inhibitors of the mixed-function-oxydase system, or in the presence of trichloroacetonitrile, a radical trapping agent (Lambotte-Vandepaer et aJ., 1981). No chromosome aberrations have been detected in the bone marrow cells of rats and mice treated with ACN (Rabello-Gay and Ahmed, 1980;Leonard et at., 1981), or in the lymphocytes of chronically exposed workers (Thiess and Fleig, 1978a). ACN induced cell transformation in Syrian golden hamster embryo cell culture; an enhancement of virus transformation was obtained in similar cells pretreated with simian adenovirus (Parent and Casto, 1979).…”

Section: Mutagenicitymentioning

confidence: 99%

See 1 more Smart Citation

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Kirsch‐Volders¹

1984

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Section: Mutagenicitymentioning

confidence: 97%

Section: Mutagenicitymentioning

confidence: 99%

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Kirsch‐Volders¹

1984

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“…After 8 weeks, 6 rats from each group were anaesthetized with ether before sacrifice. The bone marrow was processed using some modifications in the method described by (Rabello-Gay and Ahmed, 1980). 1-Colchicine (BDH Chemicals Ltd Poole, England) was prepared as 0.5% solution and injected intramuscularly in the rats at a dose of 0.25 ml/100 gm body weight.…”

Section: -Chromosomal Studymentioning

confidence: 99%

Neurotoxic and Genotoxic Potentials of Short Term Copper Exposure in Adult Male Albino Rats (Biochemical, Histopathological, Immunohistochemical and Genotoxic Study)

Mostafa

Alaaeldin

Abouhashem

2015

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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All rights reserved. Cu-containing intrauterine devices (Cu-IUDs) (Arnal et al., 2011). It has been shown that chronic exposure to Cu ions by farmers handling agrochemicals and women using Cu-IUDs leads to elevated levels of Cu in the plasma (Arnal et al., 2010). Cu is administered parenterally to individuals unable to ingest food by oral or parenteral routes and dialysis patients receiving dialysis via Cu tubing, and in cholestatic infants maintained for long periods on intravenous total parenteral nutrition (Frem et al., 2010). The widespread potential for human exposure to copper occurs via consumption of food and water Abstract Objective: Although copper is an essential micronutrient involved in a variety of biological processes indispensable for sustaining life yet it can be toxic when administered in excess. Material and Methods: Thirty six adult male albino rats were equally divided into three groups; the first group was used as a negative control, the second group received normal saline intraperitoneal (positive control group) and the third group received copper chloride 7mg/kg twice weekly intraperitoneal for 8 weeks (treated group). At the end of the experimental period, blood was withdrawn for measuring serum malondialdhyde (MDA) and catalase (CAT), then the rats were sacrificed and the brain was examined by light microscope for detecting histopathological changes. Brain sections were examined immunohistochemically for the detection of the apoptotic BaX protein and finally, the bone marrow was examined for detection of chromosomal aberrations. Results: In Cu chloride treated group (group III), there was a significant elevation in serum malondialdehyde & a significant decrease in serum catalase. Histopathological changes were in the form of increased cellularity of astrocytes, swelling of astrocytes that showed dense eosinophilic cytoplasm, with pyknotic nuclei and multiple apoptotic bodies. Also, there were degenerated neurons with deep eosinophilc cytoplasm using light microscope and BaX showed strong immunoreactions in the brain. Bone marrow showed significant increase in all types of chromosomal aberrations after 8 weeks of Cu chloride treatment. Conclusion: From the previous results, it can be concluded that Cu chloride exposure can induce oxidative stress changes in the form of a significant increase in MDA and significant decrease in CAT enzyme as well as histopathological changes in the brain and genotoxicity in adult male albino rats after short term exposure.

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“…Thiess and Fleig (1978) 66) studied whether of not chromosomal aberrations of peripheral lymphocytes would increase in workers exposed to 1.5-5 ppm (estimated levels) of AN for an average of 10-15 years, and found no changes in the incidence of chromosomal aberrations. Rabello-Gay and Ahmed (1980) 67) showed that treatment of mice orally with 7-21 mg/kg/day of AN for 4-30 days did not result in increased chromosomal aberrations of bone marrow cells. Leonard et al (1981) 68) reported that AN had negative results in both micronucleus test using murine erythrocytes and dominant lethal test using germs cells from male mice.…”

Section: Mutagenicitymentioning

confidence: 99%

Carcinogenicity and Other Health Effects of Acrylonitrile with Reference to Occupational Exposure Limit.

SAKURAI

2000

INDUSTRIAL HEALTH

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The occupational exposure limit for acrylonitrile (AN) has been set by many organizations on the basis of its carcinogenicity. However, recent epidemiological studies do not afford evidence supporting the hypothesis that AN is carcinogenic to humans. Review of the 18 published cohort studies revealed that, although there is not adequate evidence in humans for carcinogenicity of AN, the possibility of a causal association between high exposure to AN and lung cancer in humans cannot be excluded. It was pointed out that carcinogenic potential of AN may be weak, if any, to humans, and the current occupational exposure limit (OEL) for AN of 2 ppm was evaluated as appropriate in view of AN exposure levels reported by epidemiological studies. Based also on review of the literature on health effects other than carcinogenicity, it was concluded that the current OEL for AN is a reasonable value and there is no need for a revision at present.

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Acrylonitrile: In vivo cytogenetic studies in mice and rats

Cited by 33 publications

References 7 publications

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Neurotoxic and Genotoxic Potentials of Short Term Copper Exposure in Adult Male Albino Rats (Biochemical, Histopathological, Immunohistochemical and Genotoxic Study)

Carcinogenicity and Other Health Effects of Acrylonitrile with Reference to Occupational Exposure Limit.

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