Acteoside inhibits PMA‐induced matrix metalloproteinase‐9 expression <i>via</i> CaMK/ERK‐ and JNK/NF‐κB‐dependent signaling

Hwang, Yong Pil; Kim, Hyung Gyun; Choi, Jae Ho; Park, Bong Hwan; Jeong, Myung Ho; Jeong, Tae Cheon; Jeong, Hye Gwang

doi:10.1002/mnfr.201000336

Cited by 32 publications

(26 citation statements)

References 48 publications

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“…Compound 121 was reported to be a potent anti-cancer drug in the treatment of fibrosarcoma metastasis. It inhibited phorbol-12-myristate-13-acetate-induced matrix metalloproteinase-9 expression via Ca 2+ -dependent calmodulin-dependent protein kinase (CaMK)/ERK and JNK/nuclear factor-κB (NF-κB)-signaling pathways [94]. Cytotoxic activities of 121 and 127 against human larynx epidermoid carcinoma, human rhabdomyosarcoma and human MCF-7 cell lines were determined with the IC 50 from 36.24 µg/mL to 64.6 µg/mL, and apoptotic cell death was observed in histological analysis [74].…”

Section: Anti-tumor Activitymentioning

confidence: 99%

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

2016

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Phenylethanoid glycosides (PhGs) are widely distributed in traditional Chinese medicines as well as in other medicinal plants, and they were characterized by a phenethyl alcohol (C 6 -C 2 ) moiety attached to a β-glucopyranose/β-allopyranose via a glycosidic bond. The outstanding activity of PhGs in diverse diseases proves their importance in medicinal chemistry research. This review summarizes new findings on PhGs over the past 10 years, concerning the new structures, their bioactivities, including neuroprotective, anti-inflammatory, antioxidant, antibacterial and antivirus, cytotoxic, immunomodulatory, and enzyme inhibitory effects, and pharmacokinetic properties.

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Section: Anti-tumor Activitymentioning

confidence: 99%

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

2016

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“…Acteoside ( Fig. 1) is a well-studied PeG that consists of several chemical groups, including caffeic acid, 3,4-dihydroxyphenylethanol, glucose, and rhamnose (Hwang et al 2010). It has been reported that acteoside has extensive biological activities including antioxidant (Chiou et al 2004;He et al 2000), anti-inflammatory (Lee et al 2005(Lee et al , 2006, hepatoprotective (Xiong et al 1999;Zhao et al 2009), cell apoptosis regulation activities (Ohno et al 2002;Xiong et al 1999;Yang and Pu 2006) and cytotoxicity against various tumor cells (Kunvari et al 1999;Lee et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Establishment of callus and cell suspension culture of Scrophularia striata Boiss.: an in vitro approach for acteoside production

2014

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In the present study, a protocol was optimized for establishment of callus and cell suspension culture of Scrophularia striata Boiss. as a strategy to obtain an in vitro acteoside producing cell line for the first time. The effects of growth regulators were analyzed to optimize the biomass growth and acteoside production. The stem explant of S. striata was optimum for callus induction. Modified Murashige and Skoog medium supplemented with 0.5 mg/l naphthalene acetic acid ? 2.0 mg/l benzyl adenine was the most favorable medium for callus formation with the highest induction rate (100 %), the best callus growth and the highest acteoside content (1.6 lg/g fresh weight). Incompact and rapid growing suspension cells were established in the liquid medium supplemented with 0.5 mg/l naphthalene acetic acid ? 2.0 mg/l benzyl adenine. The optimum time of subculture was found to 17-20 days. Acteoside content in the cell suspension was high during exponential growth phase and decreased subsequently at the stationary phase. The maximum content of acteoside (about 14.25 lg/g cell fresh weight) was observed on the 17th day of the cultivation cycle. This study provided an efficient way to further regulation of phenylethanoid glycoside biosynthesis and production of valuable acteoside, a phenylethanoid glycoside, on scale-up in S. striata cell suspension culture.

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“…Although the anti‐tumor activity of VB is widely accepted, the precise mechanism of its anti‐metastatic potential in OSCC cells is unclear. MMPs play an important role in tumor invasion, angiogenesis, inflammatory tissue destruction and cancer cell metastasis . Among the human MMPs reported to date, MMP‐2 and −9, which are expressed abundantly in various malignant tumors, contribute to cancer invasion and metastasis .…”

Section: Discussionmentioning

confidence: 99%

“…MMPs play an important role in tumor invasion, angiogenesis, inflammatory tissue destruction and cancer cell metastasis . Among the human MMPs reported to date, MMP‐2 and −9, which are expressed abundantly in various malignant tumors, contribute to cancer invasion and metastasis . Intriguingly, NF‐κB has also been found to regulate the expression of MMPs, especially the expression of MMP‐9, which degrades and reshapes the extracellular matrix to enhance invasion of tumor cells .…”

Section: Discussionmentioning

confidence: 99%

Effect of verbascoside on apoptosis and metastasis in human oral squamous cell carcinoma

Zhang

Yuan

et al. 2018

Intl Journal of Cancer

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Despite significant advances in therapy, the 5-year survival rates for patients with advanced stage oral cancers still remains poor as an appropriate treatment has not been found yet, due to side effects of chemo/radiotherapy. Verbascoside (VB), a major bioactive constituent of the Tsoong herb, displays pharmacological properties by exhibiting anti-oxidative, anti-inflammatory and anti-cancer activities. However, the underlining function and mechanism of VB in human oral squamous cell carcinoma (OSCC) remains unclear. In this study, we show that VB significantly decreased the viability and metastasis of HN4 and HN6 tumor cells, while promoting apoptosis. A xenograft OSCC mouse model further showed that intraperitoneal injection of VB strongly inhibited growth and lung metastasis of implanted tumor cells. Immunoblot analysis confirmed that VB effectively suppressed nuclear factor (NF)-κB activation and downstream Bcl-2/Bcl-XL expression, resulting in increased OSCC cell apoptosis. In addition, VB suppressed mRNA and protein expression of matrix metalloproteinase-9 via suppression of NF-κB activation, thereby inhibiting tumor cell metastasis. Inspiringly, compared to cisplatin-treated group, VB is a biocompatible agent without signficant side effects in vivo. Collectively, our results demonstrate that VB effectively inhibits OSCC tumor cell growth and metastasis via suppression of IκB kinase complex (IKK)/NF-κB-related signaling activation, suggesting that VB has potential use as a potent anticancer agent in OSCC therapeutic strategies.

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Acteoside inhibits PMA‐induced matrix metalloproteinase‐9 expression via CaMK/ERK‐ and JNK/NF‐κB‐dependent signaling

Abstract: Acteoside inhibited PMA-induced invasion and migration of human fibrosarcoma cells via Ca(2+) -dependent CaMK/ERK and JNK/NF-κB-signaling pathways. Acteoside therefore has the potential to be a potent anticancer agent in therapeutic strategies for fibrosarcoma metastasis.

Cited by 32 publications

References 48 publications

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

Establishment of callus and cell suspension culture of Scrophularia striata Boiss.: an in vitro approach for acteoside production

Effect of verbascoside on apoptosis and metastasis in human oral squamous cell carcinoma

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