1999
DOI: 10.1038/sj.ijo.0800838
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ACTH and cortisol response to combined corticotropin releasing hormone-arginine vasopressin stimulation in obese males and its relationship to body weight, fat distribution and parameters of the metabolic syndrome

Abstract: OBJECTIVES: To investigate the activity of the hypothalamic ± pituitary ± adrenal (HPA) axis in male obesity and its relationship with several prominent parameters of the metabolic syndrome. DESIGN: A cross-sectional clinical study of the activity of the HPA axis in groups of obese males and normal-weight controls. SUBJECTS: Seventeen obese non-diabetic males with a body mass index (BMI) b 28 and eight normal-weight controls were examined. MEASUREMENTS: Fat free mass (FFM) and fat mass (FM) were measured by bi… Show more

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Cited by 81 publications
(54 citation statements)
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“…More convincingly, recent large studies confirm that total cortisol production rate is somewhat enhanced in obesity in men as well as women Fraser et al, 1999;Stewart et al, 1999). This is further supported by evidence that HPA axis responsiveness to stimuli such as acute stress, CRH/AVP (Pasquali et al, 1999), adrenergic manipulations (Pasquali et al, 2000), hypoglycaemia, or a standard meal (Marin et al, 1992;Hautanen and Adlercreutz, 1993) is enhanced in idiopathic obesity, particularly visceral obesity (Pasquali et al, 2000). Moreover, the cortisol response to particular types of food may differ with the locus of adiposity, as viscerally obese women show lower HPA axis responses to high-fat and protein but greater responses to high-carbohydrate meals, compared to peripherally obese and lean subjects (Vicennati et al, 2002).…”
Section: B the Hpa Axis And Cortisol Dynamics In Obesitysupporting
confidence: 54%
“…More convincingly, recent large studies confirm that total cortisol production rate is somewhat enhanced in obesity in men as well as women Fraser et al, 1999;Stewart et al, 1999). This is further supported by evidence that HPA axis responsiveness to stimuli such as acute stress, CRH/AVP (Pasquali et al, 1999), adrenergic manipulations (Pasquali et al, 2000), hypoglycaemia, or a standard meal (Marin et al, 1992;Hautanen and Adlercreutz, 1993) is enhanced in idiopathic obesity, particularly visceral obesity (Pasquali et al, 2000). Moreover, the cortisol response to particular types of food may differ with the locus of adiposity, as viscerally obese women show lower HPA axis responses to high-fat and protein but greater responses to high-carbohydrate meals, compared to peripherally obese and lean subjects (Vicennati et al, 2002).…”
Section: B the Hpa Axis And Cortisol Dynamics In Obesitysupporting
confidence: 54%
“…More convincingly, recent large studies confirm that total cortisol production rate is somewhat enhanced in obesity in men as well as women Fraser et al, 1999;. This is further supported by evidence that HPA axis responsiveness to stimuli such as acute stress, CRH/AVP (Pasquali et al, 1999), adrenergic manipulations (Pasquali et al, 2000), hypoglycaemia, or a standard meal (Marin et al, 1992;Hautanen and Adlercreutz, 1993) is enhanced in idiopathic obesity, particularly visceral obesity (Pasquali et al, 2000). Moreover, the cortisol response to particular types of food may differ with the locus of adiposity, as viscerally obese women show lower HPA axis responses to high-fat and protein but greater responses to high-carbohydrate meals, compared to peripherally obese and lean subjects (Vicennati et al, 2002).…”
Section: B the Hpa Axis And Cortisol Dynamics In Obesitysupporting
confidence: 63%
“…Increased resistance in aqueous outflow could also be attributed to the raised haematocrit in obese individuals. The exaggerated cortisol response in obesity could also be another cause [21,22]. Higher incidence of hypertension in obese subjects could also be indirectly linked to higher IOP in them.…”
Section: Discussionmentioning
confidence: 99%