Acth Content of Rat Pituitary Glands

Birmingham, Marion K.; Kurlents, Erika; Rochefort, G. J.; Saffran, Murray; Schally, A. V.

doi:10.1210/endo-59-6-677

Cited by 26 publications

(4 citation statements)

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“…at the pituitary gland, upon hypothalamus or other central nervous system structure( 7), or even by a direct action upon the adrenal gland itself (8,9). Regardless of the site of action, our results suggest that the acute administration of hydrocortisone, while effectively preventing the ascorbic acid depletion response to stress, acts merely to depress the basal level, or physiological "set" from which the corticoid component of the stress mechanism is 0perating.t This interpretation is further supported by the absolute increase in corticosterone concentration which occurred following stress in both groups.…”

Section: Resultsmentioning

confidence: 99%

Corticoid Response to Stress in the Steroid-Inhibited Rat

Schapiro¹,

Geller²,

Eiduson³

1962

Experimental Biology and Medicine

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Section: Resultsmentioning

confidence: 99%

Corticoid Response to Stress in the Steroid-Inhibited Rat

Schapiro¹,

Geller²,

Eiduson³

1962

Experimental Biology and Medicine

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“…The pituitaries from these animals were analyzed for ACTH content by a modification of the plasma ACTH radioimmunoassay. The plasma method was modified to permit pituitary content determinations as follows: Pituitaries were weighed, homogenized in glacial acetic acid in a siliconized glass tissue grinder, and then extracted according to the method of Birmingham et al (6). An aliquot of the extract was carried through the immunoassay.…”

mentioning

confidence: 99%

The Importance of Stimulus Intensity and Duration of Steroid Administration in Suppression of Stress-Induced ACTH Secretion

et al. 1972

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The ACTH-releasing activity of two stimuli, lysine vasopressin and epinephrine, was studied at time intervals ranging up to three days after beginning dexamethasone administration. Male rats were given a large pulse dose of dexamethasone to suppress ACTH secretion and the suppression was continued by the administration of dexamethasone in the drinking water. At intervals thereafter, the rats received graded doses of vasopressin or epinephrine. Twenty minutes later, blood was taken for corticosterone determination. The plasma corticosterone response to both stimuli fell progressively with longer durations (and cumulative total amount) of dexamethasone pretreatment. However, the greater the stimulus applied, the longer was the period of time required for suppression of the plasma corticosterone response. While adrenocortical responsiveness to exogenous ACTS also diminished with time, diminished adrenocortical responsiveness alone did not account for the depressed responses to the stimuli as evidenced by the fact that vasopressin-induced increases in plasma ACTH concentration also fell progressively after beginning dexamethasone. Pituitary ACTH content was not significantly affected by the dexamethasone administration. It is concluded that both the duration of prior corticosteroid administration and the intensity of an ACTH-releasing stimulus are important determinants of pituitary-adrenal activation. {Endocrinology 90: 525, 1972)

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“…Pituitary ACTH content was measured by a modification [19] of the adrenal slice bioassay of Saffran and Schally, i.e., corticosterone production was determined by using a fluorescent technique [ 16], Pituitary glands were extracted in glacial acetic acid according to the method of Birmingham et al [22]. The capacity of the pituitary gland to release ACTH was assessed in vitro by utilizing a modification [23J of the CRF bioassay procedure of Saffran and Schally.…”

Section: Methodsmentioning

confidence: 99%

Effect of the Growth Hormone-Secreting Tumor StW5 on Pituitary and Adrenal Gland Function in Rats

Coyne¹,

Alpert²,

Harter³

et al. 1981

Horm Res

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A growth hormone-secreting tumor (StW5) was implanted into male rats and resulted in a tripling of adrenal weight concomitant with a 30% decrement in pituitary weight. Plasma concentrations of corticosterone in tumor-bearing (TB) rats were significantly elevated at rest or after ACTH injections or the stress of ether anesthesia. The rise in plasma concentrations of corticosterone was due mainly to the large increment in adrenal size although a significant increase in adrenal responsiveness to ACTH was demonstrated in vitro. In addition, plasma corticosterone concentrations were higher in TB rats despite both a doubling of the blood volume and a 50% increase in liver capacity to metabolize corticosterone. Pituitary ACTH content was significantly lower in TB rats, but these pituitary glands could still release near-normal quantities of ACTH as shown both by in vitro incubations and adrenal corticosterone output following ether stress.

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Acth Content of Rat Pituitary Glands

Cited by 26 publications

References 0 publications

Corticoid Response to Stress in the Steroid-Inhibited Rat

Corticoid Response to Stress in the Steroid-Inhibited Rat

The Importance of Stimulus Intensity and Duration of Steroid Administration in Suppression of Stress-Induced ACTH Secretion

Effect of the Growth Hormone-Secreting Tumor StW5 on Pituitary and Adrenal Gland Function in Rats

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